Dave thanks for sharing this. If you felt you had enough time you might enjoy the Free 6 week course run by Future learn out of Bath University. Several people on this forum have done it including me. It is called Inside cancer: How genes influence cancer development. There is a new course starting in about 6 weeks time I think. I found it took me about 3 - 4 hours a week and I usually hit it all in one go on the Monday after that week's course material had been downloaded. No technical issues even when I was in USA for 4 weeks of it. I am no academic either but I managed to keep up.
It is not PCa specific but that does not matter and there are some parts of the course where you can tailor your response for PCa.
The article you are talking about here is hitting on one of the course topics and that is how the DNA strands can change their sequence from normal healthy cells into mutated non cancerous and then mutated cancerous ones. I guess this is why margins are taken during surgery etc.
I had no idea until I did this course how cancer worked its evil (and believe me there were things I learned that make me feel very justified in describing it like that) or indeed how anyone would ever start to go about about researching for a cure. When you get to know a tiny little bit for example about how cell death can be artificially stopped or started, or how certain cell processes can be targeted to change cell behaviour etc. It helps to explain a lot of things.
I think it is designed to give just enough insight and knowledge to make you want to learn and possibly understand more.
In a rather weird way it helped me to understand better how, and to some extent why Mick died and why treatments just did not work for him. It also gave me a lot of hope for others. Just knowing how much knowledge and how many amazingly gifted scientists are out there working their magic gives me real hope that a far better screening/detection method with potentially a less invasive cure and far less debilitating treatments will become a reality. Possibly even in my lifetime.
Gosh I hadn't expected all that to come out ..sorry if it is TMI etc.
xx
Mo