Disappointing day today PSA doubled to 27 in 4 weeks, 3rd consecutive rise. After a great start on enzalutamide 7 months ago and a very fast reduction to 4 this feels like a set back. CT and bone scans are being booked for 3 weeks time. Hubby already has bone mets in rib and pelvis but feels really well and no pain. Has anyone had a rise in PSA on enzalutomide but no further bone or lymph mets? Is it right to always assume that a rise in PSA means treatment isn’t working? Would appreciate any in put.