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Bicalutamide failure

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User
Posted 23 May 2018 at 19:02

I was started on 150 mg Bicalutamide in December 2017 psa 60.. Radical prostatectomy planned for June.

However, psa now rising quickly - from 6 to 12 in about 6 weeks.

Should I now stop taking Bicalutamide? - I have read that it can actually start to 'feed' the cancer, though my oncologist is inclined to stick with it.

And is there any chance now of Lupron or similar now working? Or is my cancer now castrate resistant? - Doesn't look good.

User
Posted 24 May 2018 at 12:26

Sorry to hear this. I don’t think it would be a good idea to stop the bicalutamide at this point.

Hopefully someone with more knowledge will come along and add details I can’t at the moment.

Best wishes,

Ian

Ido4

User
Posted 24 May 2018 at 14:11

I’m assuming that your prostatectomy is still scheduled? I dont think you should stop taking the bicalutamide without talking to your oncologist or specialist nurse.

best of luck

User
Posted 24 May 2018 at 16:11
It doesn't make you castrate resistant because bicalutimide doesn't castrate you - it simply disguises the testosterone so that the cancer can't find it - apparently yours has now found it. Your onco could decide to move you onto a different kind of HT which actually stops the testosterone from being produced in your body.

I am a bit surprised that you are having hormones pre-op - very unusual

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 24 May 2018 at 18:31

I thought the reason they were given pre op was to make he tumour smaller and easier to deal with?? 

User
Posted 24 May 2018 at 18:48
I was offered Bicalutamide pre op , but why has your op been scheduled 6 months away ??? Far too long. Are you sure it isn’t RT you are having ?
User
Posted 25 May 2018 at 15:07

Originally Posted by: Online Community Member

I thought the reason they were given pre op was to make he tumour smaller and easier to deal with?? 

I think that's definitely the case if you are having radiotherapy. When I was diagnosed and offered the choice of radiotherapy or surgery I was told that I would only have hormone treatment if I opted for radiotherapy so, as Lynn says, having it before surgery does seem unusual.

User
Posted 25 May 2018 at 16:42

Originally Posted by: Online Community Member

Originally Posted by: Online Community Member

I thought the reason they were given pre op was to make he tumour smaller and easier to deal with?? 

I think that's definitely the case if you are having radiotherapy. When I was diagnosed and offered the choice of radiotherapy or surgery I was told that I would only have hormone treatment if I opted for radiotherapy so, as Lynn says, having it before surgery does seem unusual.

Suggest you call your consultants secretary and get them to confirm why you are having it - informed consent is a key requirement of a doc / patient reltionship. 

 
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