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Recurrence?

User
Posted 11 Sep 2017 at 12:44

I had radiotherapy for Prostate cancer 13 years ago  (I am now 68) and all has been well with PSA levels down to almost zero. I even forgot to have my PSA checked last year, it just never entered my mind. I had a blood test a couple of weeks ago for something else and asked them to do a PSA one too, which they did.  The result showed an increase from near zero to 4.7. I have no infection that i know of or any other pains. Anyone able to advise on what is happening? 

User
Posted 18 Sep 2017 at 11:39

Thank you for that info Dave and Andrew. It was quite a shock as it had all gone out of my mind and didn't even have a PSA test last year. My readings were less than .1 five yrs ago but not bothered to check since. Just found out today that in 2015 it had doubled to 1.49. I was not informed of this!
Urine infection has been ruled out. So being referred to the local hospital in the normal 2 weeks.
Interested to hear about your experience Dave.

User
Posted 26 Oct 2017 at 12:11

Much better than a poke in the eye with a sharp stick!


I don't think that gout itself is significant - but the treatment might be.


This research was in patients with prostatitis, but the effects might be similar in PCa


 


Allopurinol treatment results in elevated prostate-specific antigen levels in prostatic fluid and serum of patients with non-bacterial prostatitis.

.
-- Andrew --
"I intend to live forever, or die trying" - Groucho Marx
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User
Posted 11 Sep 2017 at 14:08

Hello Davee

I can't be of much help with your question but I'm sure that others will advise you.

You say you have no infection that you know of but is that based on how you feel as I assume that the GP has checked you for infection

Has your GP referred you back to the hospital?

We can't control the winds - but we can adjust our sails
User
Posted 11 Sep 2017 at 16:48
I would suggest that you see your g.p and ask that he/she refer you back to the hospital for further tests and checks. Good luck
User
Posted 13 Sep 2017 at 10:13

I'd get a repeat test, just in case it was an aberration - but also think carefully about any signs and symptoms.


If the repeat test is as high, then time for investigations.


Good Luck!

.
-- Andrew --
"I intend to live forever, or die trying" - Groucho Marx
User
Posted 14 Sep 2017 at 10:38

Hi Davee,


As others have pointed out, one test alone doesn't prove anything, I guess further tests/scans etc may be needed.


I see like me you had radiotherapy some years ago, I guess you were told at the time that you could only ever have one bout of radiotherapy.  If it worked it worked, if not then it was hormone therapy for the rest of your life?


That has changed, if you check my profile there are all the details of salvage HDR brachytherapy.  'Fingers crossed' it is working for me, and even if it is not it is buying me a lot of time with my PSA bumping along at currently a mere 0.5


So hopefully you don't have a reoccurrence, but if you do please be aware that science has moved on and new treatments are available.


:)


Dave

User
Posted 18 Sep 2017 at 11:39

Thank you for that info Dave and Andrew. It was quite a shock as it had all gone out of my mind and didn't even have a PSA test last year. My readings were less than .1 five yrs ago but not bothered to check since. Just found out today that in 2015 it had doubled to 1.49. I was not informed of this!
Urine infection has been ruled out. So being referred to the local hospital in the normal 2 weeks.
Interested to hear about your experience Dave.

User
Posted 19 Sep 2017 at 09:48

Hello yes urine tests were neg. Referred to local hospital in next 2 weeks.

User
Posted 26 Oct 2017 at 11:43

Latest blood test is down to 4.3 from 4.7 ?? Urologist examined my prostate and commented that it was small He is deciding what to do. I have no symptoms at all. I have had bad Gout for last 2 years dont know if that can be connected?

User
Posted 26 Oct 2017 at 12:11

Much better than a poke in the eye with a sharp stick!


I don't think that gout itself is significant - but the treatment might be.


This research was in patients with prostatitis, but the effects might be similar in PCa


 


Allopurinol treatment results in elevated prostate-specific antigen levels in prostatic fluid and serum of patients with non-bacterial prostatitis.

.
-- Andrew --
"I intend to live forever, or die trying" - Groucho Marx
User
Posted 26 Oct 2017 at 14:24

That's interesting Andrew. I have having Allopurinol for gout at 300mg rather than earlier 100mg daily for long before being diagnosed with PCa, so haven't checked the info literature that comes with it which presumably mentions this. Although my treating consultants should have been aware of this from my records, none of them mentioned it as a potential source for increasing PSA.

Barry
User
Posted 26 Oct 2017 at 17:43

A possibility worth discussing with the medics - PSA is notoriously easily distorted!

.
-- Andrew --
"I intend to live forever, or die trying" - Groucho Marx
User
Posted 30 Oct 2017 at 11:57

I was told their decision re what they intend to do. They consider the PSA reading which is now 4.3 does not justify any immediate action. They have suggested if it reaches 10 then they will do a MRI scan. Im not happy about this as I shouldn't have a significant reading at all after having had Radical RT. It also appears the committee were not told I had had RT. :-(

User
Posted 30 Oct 2017 at 15:19

Davee, RT doesn't destroy the prostate, so you should still have a positive reading, close to normal, say 4 I reckon the advice you have been given is sound, subject to resolving the issue about your medication.

AC

User
Posted 30 Oct 2017 at 15:23

Hi Davee


 


You mentioned you had a "Radical RT".....do you mean RP (radical prostatectomy)?


If you still have your prostate...then some PSA will still be detected and produced.


IF you had an RP...then I think ANY PSA would indicate Mets.


BC

Edited by member 30 Oct 2017 at 15:25  | Reason: Not specified

User
Posted 30 Oct 2017 at 20:02

Bill, Daveee had radical RT - radical simply means that it was the primary treatment.

Davee, your prostate will have recovered somewhat and the healthy prostate cells will be generating PSA. The level has gone high enough to be concerned but you can't have any more RT so what would you want the doctors to offer you as a treatment? Hormone therapy would be long term now and does not last forever so perhaps the MDT are trying to delay starting HT for as long as they can? Have they said how high your PSA needs to go before they put you back on treatment?

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard
 
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