Have a look at this news item from Prof de Bono and the Institute of Cancer Research:
https://www.icr.ac.uk/news-archive/men-with-incurable-prostate-cancer-living-twice-as-long-as-decade-ago
The Prof was Spurspark’s consultant and much of the testing and trialling that Spurspark was willing to put himself through (including being the first person on here to take Abbi) is benefitting current members more than they could ever imagine.
This is interesting. The drug in question is already used widely for autoimmune disease.https://www.icr.ac.uk/news-archive/immunotherapy-drug-for-skin-disease-could-boost-hormone-treatment-for-prostate-cancer
Edited by member 19 Jul 2018 at 18:24 | Reason: Not specified
Another novel approach to castration-resistant PC treatment:
https://labiotech.eu/medical/cellcentric-prostate-cancer-epigenetic/
This is a nice summary of bipolar androgen therapy (BAT) by Sam Denmeade, the doctor who invented it:
http://www.hematologyandoncology.net/archives/june-2018/bipolar-androgen-therapy-in-the-treatment-of-prostate-cancer/
It's particularly interesting that in a trial for checkpoint inhibitor immunotherapy, both of the patients who responded very well had previously been through BAT. Dr Denmeade is now proposing to trial this combination. He's at Johns Hopkins in Baltimore, USA.
This recent paper shows remarkable results in metastatic PC using targeted alpha therapy, 225-Ac-PSMA.
https://www.ncbi.nlm.nih.gov/pubmed/30232539
The study was done in South Africa. I know that this treatment originated in Germany, but I don't think it's available yet in Britain, unfortunately.
For anyone who is having (or thinking of having) a PSMA-based treatment, such as Lu-177, the following preliminary study may be of interest. It appears that use of enzalutamide before the treatment increases the expression of PSMA, thus potentially making the treatment more effective. Clever!
https://scienmag.com/nuclear-radiologists-outsmart-prostate-cancer-with-an-apparently-ineffective-drug/
Hi Dark warrior
thanks for posting this interesting article. I completed 6 infusions of Docetaxel by August last year, however as my PSA had gone back up by Feb this year I re started a course of 10 Cabazitaxel in March. I’ve had 7 so far with no real ill effects ( still golfing, gardening, walking etc), with No 8 due on the 1st Aug. However PSA not reducing as much as when on Docetaxel so I’m off up to Bristol on Monday for a consultant clinic re-Radium 223. So it looks as if 5 years on from your article I’m following a similar path? Let’s hope it doubles my survival time too?!
Keep the Faith
J..
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