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Docetaxel + Darolutamide + Zoladex (LHRH)

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User

Posted 22 Feb 2023 at 19:24

Was back in A&E today, this time for chest pains (intensifying heart palputation type pain where pain would rush towards the centre of my chest in time with my pulse to the point it felt like something was gonna burst out). Most of yesterday I had it but it wasn't so strong so I wasn't too worried, but then I woke at 2am with a more intense version of it that I couldn't just "relax" away.

Went to A&E and ended up there for 12 hours :( They did all various tests, ecg, bloods, ultrasound, CT with dye, but they all discarded any serious underlying issue that would normally cause such pain, including checking the aorta. So the verdict was it was likely just a pain I got this time around on the Docetaxel and I just have to deal with it. Which is easier that I've now been checked out, but 12 hours in an A&E while in early fatigue stage of chemo was no fun. Thanks to the Pelgraz injection this time round though I wasn't neutropenic, white cells were actually elevated.

User

Posted 22 Feb 2023 at 20:06

Sorry to hear that you a reaction to the chemo.

Do you mind me asking which a&e that you went to, as that seems like an amazing assessment. In my local a&e they just see you and kick you out the front door without any investigation or follow up!

User

Posted 23 Feb 2023 at 06:55

It was QEQM. In Margate. They were quick to triage, but I didn't get to see the first doctor until 9 hours after, because they are just so overwhelmed. But I felt they were professional and caring once my time came, and they weren't scared to add on further tests.

User

Posted 23 Feb 2023 at 20:39

Must have been difficult to wait for so long. At least you know you have been thoroughly investigated.

User

Posted 24 Feb 2023 at 06:56

1 week now after my 2nd Chemo session. Chest pains have thankfully reduced to background levels, muscles still aching but that's all easy to deal with. One thing that's hit me harder this time is sore tongue, I've tried to be careful with hot and cold and I use a toothpaste that doesn't have the foaming agent in. I'm hoping soft tissues get a chance to recover before the 3 week cycle of chemo.

User

Posted 24 Feb 2023 at 07:09

You might have a fungal infection of the tongue, might be worth asking your GP?

User

Posted 24 Feb 2023 at 07:42

Ah no it's not that bad, it's just a slow progression to soreness since it has trouble regenerating the cells. I was expecting it but just didn't know if typically you get enough time before the next chemo for it to heal, otherwise it could get nasty over the longer term.

User

Posted 24 Feb 2023 at 10:21

I have been prescribed three treatments to avoid mouth issues and reflux.

Bioextra gentle mouthwash - 2xdaily

Mycostatin oral drops - 2xdaily (for fungal infection)

Pantoprazole daily for reflux

No issues after 5 chemo sessions. Might be worth asking about the mouthwash and Mycostatin to see if it helps. Good luck.

Edited by member 24 Feb 2023 at 10:23 | Reason: Not specified

User

Posted 24 Feb 2023 at 17:23

Assuming you have no heart problems, the best solution for mouth soreness / ulcers / the horrible metallic taste is to suck frozen pieces of fresh pineapple during the infusions. If you can't have pineapple because of your heart, ice cubes are a good substitute

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User

Posted 24 Feb 2023 at 17:42

Thank you, I will try that. I remember it was mentioned before (several times) and I forgot.

User

Posted 10 Mar 2023 at 09:01

3rd chemo yesterday. No real dramas, but I was very apprehensive after the last one gave me bad chest pains, so I did ask them to stop soon after I felt some mild chest pains and they changed the egress rate on the IV to half speed. We're going to keep it like that for the remaining ones too. Not too bad since it's only a 1hr IV normally. Half way through my Docetaxel now.

I did get my new PSA reading back of 23.1.

PSA history to date:

12th Dec 2022 990
11th Jan 2023 218
7th Feb 2023 62
9th Mar 2023 23.1
30th Mar 2023 13.2 (just before 4th chemo) I will edit this msg for PSA readings from now on.

Edited by member 31 Mar 2023 at 03:50 | Reason: new PSA reading to add

User

Posted 17 Jul 2023 at 12:11

Thought I'd give a bit of an update on my treatment.

I completed my 6th and last Chemo session on 11th May 23
I had bilateral subcapsular Orchidectomy on 3rd July 23
Had spacer insertion in prep for 6x VMAT radiotherapy sessions, but have postponed or cancelled RT until further notice as I'm battling high BP and other issues and just can't deal with RT right now.

20 Apr PSA 10.4
11 May PSA 6.67
1 June PSA 5.87
29 June PSA 1.99
27 July PSA 0.65

Subjectively though I do seem to be having some pains and side effects, like my eyesight has worsened quite a bit, and I have a few painful areas in my torso that feel like pulled muscles but don't seem to disappear after after months.

I'm having to get weekly blood tests due to some liver function results that are higher than they should be. I'm not sure yet but it could be leading to me coming off the Darolutamide if my body is getting tired of it.

Edited by member 31 Jul 2023 at 11:27 | Reason: Added new PSA reading

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