Stampede Trial Arm J Zytiga and Enzalutamide

Hi Paul

I envy you that arm http://community.prostatecanceruk.org/editors/tiny_mce/plugins/emoticons/img/smiley-laughing.gif

I started on STAMPEDE in March 2008 on the Zometa (Zoledronic Acid) arm and have no regrets. Despite a very poor prognosis I am still here http://community.prostatecanceruk.org/editors/tiny_mce/plugins/emoticons/img/smiley-laughing.gif. In hindsight I would probably have preferred the Chemo arm but then that's splitting hairs.

Good luck and keep us informed of your progress http://community.prostatecanceruk.org/editors/tiny_mce/plugins/emoticons/img/smiley-laughing.gif

Hi ANJ

I have just read the article below and it seems that this is one of the arms available, hope it helps

"In the normal course of events node-positive prostate cancer has typically been excluded from clinical trials. This leaves our oncologists with little evidence to guide the management for those of us who have this flavor of prostate cancer.

A recent anaylisis presented at the European Society for Medical Oncology (ESMO) 2014 Congress begins to shed some light on the management of node positive prostate cancer. The evidence presented indicated that radiotherapy (to the pelvis and lymph nodes) added to androgen-deprivation therapy (ADT) improves survival.

In a post hoc analysis of the control arm of the phase III STAMPEDE trial it was shown that the addition of radiation to androgen-deprivation therapy prolonged failure-free survival, an endpoint that included biochemical failure, disease progression, or death, in men with high-risk prostate cancer, including both node-negative and node-positive cancers.
Radiation plus androgen-deprivation therapy should be considered standard of care for node positive prostate cancer just like it is already considered the standard of care for high-risk node-negative men".

Si

Hi Anj, I am just starting my my  fourth  month now on Arm J .No side effects and PSA has come down from 124 to 0.8 . There are three  arms to this clinical trial Arm A which is the standard hormone therapy with additional check ups .Arm H which adds radiotherapy to HT. and arm  J which adds Zytiga and Enzalutamtide to HT. As to which Arm you get is down to computer generation.

I was diagnosed in January 2015 aged 52 with stage 4 prostate cancer my PSA was 110 and was started on HT the day after diagnosis my PSA was down to 3.6 in five weeks so well happy I was then told there was spread to lymph nodes but not to bones had biopsy was told large aggressive tumour gleason score 8 I was asked if I wanted to go on stampede trials and was chosen for arm J which I started yesterday as far as im concerned I have nothing to lose and hopefully something to gain

Edited by member 06 May 2015 at 09:55  | Reason: Not specified

Hello

I'm bumping this back up again to see how everyone on this Stampede Group J are doing.

I'm still plodding along after 6 months on the trial with my Psa now at .07 but with hourly hot flushes, aches in the tummy, bouts of diahorea, leaden legs and arms and slightly more tired ( prob due to not sleeping well)

I still try to run but am finding it harder but am persisting.

My ALT liver stat which had gone skyward is now down to 58 (spec is 0 to 40) and my ALP is and always has been ok and is at 89. All my other stats are ok.

My next appointment with my Oncologist is Monday , this after 6 weeks.

I just wondered how everyone else on this trial was doing.

Hello all.

I have been offered STAMPEDE Group A or J, but my Oncologist couldn't recommend whether to do it or not.  I have read up on it (lots of info on http://www.stampedetrial.org/) and have a meeting tomorrow with the Oncology Research Nurse who is running the trial at my local Hospital.  My 2 questions are: quantify benefits of Group J versus side effects / quality of life; quantify effect of delaying RT for 6 months.

At the moment I'm just on Hormone Therapy so currently have few side effects.  Taking Abiraterone, Enzalutamide and Prednisolone all potentially have significant side effects.  I'm concerned if that is going to be more pain for little gain.  I understand that RT will be delayed for 6 months from the start of the trial for Group A or J.  Other studies indicate that RT should be done as soon as possible for maximum benefit.

So a difficult decision to make, will let you know what I decide.

Good luck to all on this journey.

Steve

X

The delay in RT is recommended now as it allows the tumour time to shrink before the RT blasts it.

Why not hit it now with everything that you can?

The additional appointments may be reassuring and you can stop at any point if you are not happy.

Lots of men on here are taking part, we did, and do not regret it, but it was a very difficult decision at the time when you are in shock of diagnosis.

Good luck.

Alison

My results keep on getting better.

My PSA is now down to 0.04

My troublesome Liver readings ALT is down again to 27 which is the lowest since I was diagnosed with PCa.

Re my stomach pains my Onco has suggested varying dosage in order to try and identify which of the 2 drugs (Enzo or Abi) are the culprits and then she will see if the revised dosage can be made and still keep me on Stampede J.

I came out after the appointment full of optimism and for the first time thinking that the Onco was fully on my side and not just running the Trial.

So anyone having difficulties deciding whether or to join the Stampede Trial I hope this experience of what support is given helps.

Edited by member 20 Jul 2015 at 21:31  | Reason: Not specified

Glad that you've made the decision on Stampede

From my point of view I've not regretted going on Stampede and the support is excellent

I'm puzzled though that they run you on the trial until your PSA gets to below 1 and then do RT. My ONCO says I stay on the trial until my PSA starts rising again. (It's currently 0.04)

Maybe this is the new procedure.

A good idea as they say hit the PCs with everything early on.

Paul