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Yentreve (duloxetine)

Posted 30 May 2015 at 20:58

I've recently been prescribed Yentreve for continuing continence problems 1 year after LRP and I wondered what other people's experience of using this drug are, before I give it a try?

I was assessed by a physiotherapist and found to be doing the pelvic floor exercises properly and have not been able to tolerate oxybutinin, tolterodine or miragegron due to side effects.

I am using cialis alternate days for ED and it does seem to help but I am unable to tolerate it on a daily basis due to side effects but find if I stop it the continence worsens and I need to use more than 1 pad per day.


Posted 31 May 2015 at 23:13

Hi Robert,
I don't know of anyone on here that has mentioned taking any of these recently but am commenting in order to bump you up the 'recent posts' list - I hope someone comes along to help you soon :-)

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

Posted 31 May 2015 at 23:15

Out of interest, what strength of Cialis are you taking? I have never seen anyone comment that it helped their incontinence before!

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

Posted 01 Jun 2015 at 13:23

I am using the 2.5mg strength. The urologist told me it can either improve or worsen the incontinence. In my case it worsens if I try stopping it and does seem to help with the ED taken alternate days. My understanding is that it has 2 direct effects on the bladder as well as an effect on blood flow. Because of the shape of the tablets they can't be cut exactly in half - I would really be better off taking half a tablet daily.

I should point out that I also have a neurological condition which is classified as 'benign' but I seem prone to the neurological side effects of drugs because of this condition.

The Yentreve is licenced for stress incontinence in women but not in men. I guess this could be because there may not be a sufficient market for it in men for the manufactures to apply for a license.  It has been given to me on private prescription by the Urologist.

Edited by member 01 Jun 2015 at 13:28  | Reason: Not specified

Posted 18 Dec 2018 at 11:46
Not sure if Robert is still there!!! Did you take the Yentreve?

I have been offered the same drug - Duloxetine / Cymbalta / Yentreve and wondered if there has been anyone who has used this drug?

Posted 18 Dec 2018 at 16:40
I can't comment on the use of duloxetine for your particular issue, but I can sound a warning note about its addictive qualities. My wife was prescribed the stuff by her neurologist to help with dystonia issues but concluded after a couple of years that it didn't really help. She has been working with her GP to reduce dosage and eventually come off it, but the side effects of extreme fatigue have caused them to pause the weaning process until after the festive season. Then the plan is to transition to another drug which is more easily weaned.

So if you must use it, beware. Those who prescribe it rarely have to confront the issues involved in coming off the drug, which is a great shame.


Posted 19 Dec 2018 at 11:20
It spooked ne when I read it was for depression and the pelvic floor thing was a side effect rather than a drug that specifically targets the incontinence problem. I've not had any feedback from people who have used it specifically for incontinence - so I suspect there aren't many!

I think I'll pop them in a drawer and revisit in 6months! I'm 18 months post Da Vinci so will plug on with the PFEs.

I have been in contact with a American woman, Vanita Gaglani ( http://vanitasrehab.com/health-topic/radical-prostatectomy/) who has written "Life after Prostatectomy and Other Urological Surgeries". The book was given to me by a friend who found it useful. I'm working with her to try new exercises to get the PF working properly.



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