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Simvastin

User
Posted 29 Jun 2015 at 09:58
My OH is taking Simvastin statins as well as all of the usual PCa drugs Prostap 3 etc following RT 2years ago.

He is finding that he has severe muscular aches and pains particularly in the arms and legs.

The GP will not swap the statins for another brand, although we are going to insist upon it at the next appointment.

Has anyone else come accross this problem and would a change of brand help?

The preliminary research suggesting that Statins may assist in holding PCa back is obviously in the forefront of our minds, so we do not wish to stop taking them all together but this muscle ache is becoming unbearable.

Any advice appreciated.

Alison

User
Posted 30 Jun 2015 at 20:40
Hi Alison

Simvastatin used to be the statin of choice for most people who satisfied the criteria for taking statins. In July 2014 new NICE guidance changed the statin of choice to Atorvastatin so GPs should be thinking of prescribing Atorvastatin for their patients. It was found that larger doses of Simvastatin (80mg) often caused muscle aches and pains. The trouble is HT can cause muscle aches and pains as well and it can start after being taken for a long time. NICE guidance advises that to check if a statin is causing muscle problems it should be stopped for a short period to see if the side effects are resolved. If they are not resolved then the statins can be restarted and other reasons considered for the aches and pains. Hope that is not too long winded!!

Best wishes

Michael

User
Posted 29 Jun 2015 at 14:33

Why do u think it is the statin and not HT? The impact of testosterone drop on our bodies manifests itself in many ways. I have been taking simvastatin for many years and cannot say I can blame them for much, though I know everyone is different.

User
Posted 29 Jun 2015 at 15:50

I used to be on simvastatin and the same effects, mentioned it to my GP and he changed then to Atorvastatin. I find them much better.

User
Posted 29 Jun 2015 at 16:44

Hi Alison,

I used to be on Simvastatin but was switched to Atorvastatin several years ago.  Never really knew why but as it was a long time prior to my PCa diagnosis so I don't think it was anything to do with that.

After my heart attack I have been put on a high dose of Atorvastatin which means that each day I take 14 different medications.  I feel like a drug addict.  Tomorrow I have my next Zoladex implant due (It's one year since I started on HT).  I hope I can stop the bleeding this time.  My heart meds mean that when I start to bleed it takes a while to stop.

I hope your husband manages to sort things out with the aches and pains.  I have had several changes of meds because they've caused me problems.

Keep in touch.

Steve

User
Posted 30 Jun 2015 at 18:50
Don't want to put the cat amongst the pigeons but I came off Atorvostatin because of leg/muscle aches. For some reason our doctor won't prescribe Simvastatin. My wife is on Atorvostatin and doesn't have any problems.

Arthur

User
Posted 30 Jun 2015 at 19:33

Hi Alison,

Might be worth searching on the internet to see if there was any problem with Simvastatin.  Seems odd that I was taken off it when I had no problems with it.

Steve 

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User
Posted 29 Jun 2015 at 14:33

Why do u think it is the statin and not HT? The impact of testosterone drop on our bodies manifests itself in many ways. I have been taking simvastatin for many years and cannot say I can blame them for much, though I know everyone is different.

User
Posted 29 Jun 2015 at 15:50

I used to be on simvastatin and the same effects, mentioned it to my GP and he changed then to Atorvastatin. I find them much better.

User
Posted 29 Jun 2015 at 16:44

Hi Alison,

I used to be on Simvastatin but was switched to Atorvastatin several years ago.  Never really knew why but as it was a long time prior to my PCa diagnosis so I don't think it was anything to do with that.

After my heart attack I have been put on a high dose of Atorvastatin which means that each day I take 14 different medications.  I feel like a drug addict.  Tomorrow I have my next Zoladex implant due (It's one year since I started on HT).  I hope I can stop the bleeding this time.  My heart meds mean that when I start to bleed it takes a while to stop.

I hope your husband manages to sort things out with the aches and pains.  I have had several changes of meds because they've caused me problems.

Keep in touch.

Steve

User
Posted 29 Jun 2015 at 18:37
Thanks everyone, so far and for the recommendation of Atorvastatin Damperman, we will ask for this to try.

Yorkhull, I only assumed it was the statins as these were started about a year ago, and the HT 3 years ago. My mum also complained of major muscle ache when on the Simvastatin and obviously she has not got PCa, but it could be a mixture of the two drugs together. You are right not to assume anything with this disease.

Steve, I know what you mean about the drug taking. When on the trial my OH had a similar amount to take per day and had to be really strict with his routine. A couple of times we got to bedtime to realise he had not taken today's tablet of one kind or another!

I hope the jab is better tomorrow. Do you know how long you will be taking it? My OH is coming off HT after 3.5 years so we are nervous about what will happen, but hopeful that holidays from it will work out better in the long run.

Good to hear from you. Keep in touch.

Thanks everyone.

Alison

User
Posted 30 Jun 2015 at 18:50
Don't want to put the cat amongst the pigeons but I came off Atorvostatin because of leg/muscle aches. For some reason our doctor won't prescribe Simvastatin. My wife is on Atorvostatin and doesn't have any problems.

Arthur

User
Posted 30 Jun 2015 at 19:33

Hi Alison,

Might be worth searching on the internet to see if there was any problem with Simvastatin.  Seems odd that I was taken off it when I had no problems with it.

Steve 

User
Posted 30 Jun 2015 at 20:40
Hi Alison

Simvastatin used to be the statin of choice for most people who satisfied the criteria for taking statins. In July 2014 new NICE guidance changed the statin of choice to Atorvastatin so GPs should be thinking of prescribing Atorvastatin for their patients. It was found that larger doses of Simvastatin (80mg) often caused muscle aches and pains. The trouble is HT can cause muscle aches and pains as well and it can start after being taken for a long time. NICE guidance advises that to check if a statin is causing muscle problems it should be stopped for a short period to see if the side effects are resolved. If they are not resolved then the statins can be restarted and other reasons considered for the aches and pains. Hope that is not too long winded!!

Best wishes

Michael

User
Posted 30 Jun 2015 at 21:18
Thank you Michael, that is an interesting point.

Edited by member 30 Jun 2015 at 21:19  | Reason: Not specified

User
Posted 08 Sep 2015 at 21:52

Hi Guys,

I have had cramp in the small muscles of my wrist, hands, feet and ankles for some years (not the clasic cramp in the major thigh or calf muscles).

Thinking about it this possibly coincided with PCa treatment such as HT.

However within six months of diagnosis of PCa, they also picked up that I had type 2 diabetes (And there is a link between Type 2 Diabetes and Zoladex but I shall leave this so not to digress).  Because I was 'diabetic' this meant that my cholestorol level, which would ordinarily have been OK, had to be lowered as higher cholestorol levels are higher risk for diabetics, so I was put on Simvastatin.

My GP had also specifically prescibed Quininne Sulphate tablets for the cramp, which tended to help.

The cramps were particularly bad if I was doing a lot of physical work, such as DIY, and at times my hands would lock up so I couldn't hold a screwdriver or chissel etc.

Recently the cramps got worse, even when I was doing nothing physical during the day, and were competing with PCa to keep me awake at night, often as not I would wake with cramp and a competing urge to pee!

So I looked up cramp on the NHS website, and surprise, surprise, statins are identified as a significant cause of cramp.

So I stopped taking Simvastatin a couple of weeks ago, and have had much better nights sleep in consequence.

From my way of thinking a good night's sleep will be better for my health, than the need to keep my cholestorol beneath some arbitary number.

I am off to see my GP in the morning, I will let you know her thoughts on this.

:)

Dave

  

User
Posted 09 Sep 2015 at 07:41
Dave

My husband was put on Simvastin for high cholesterolbut it didn't agree with him at all, he was then changed to another statin and now has no problems. Simvastin is out of patent so is usually prescribed first but there are several alternatives.

Good luck with your appointment.

Maureen

"You're braver than you believe, stronger than you seem and smarter than you think." A A Milne
User
Posted 09 Sep 2015 at 11:30

The body reacts in so many different ways it can be hard to ascribe changes to one cause. I am type 2 diabetic, take a host of drugs including simvastatin and been on HT for over three years. I don't think I have had any problems with the statins and my diabetic scores are in control which is one less problem to worry about when fighting PCa. When so many drugs are taken they can react with each other and we have to try changes to see if they will work for us.

User
Posted 09 Sep 2015 at 16:40

For what its worth...without being Mr Doom & Gloom,

I was on Simvastatin for a number of years, 

however I was given a routine blood test a few months ago and my CK ( Creatin Kinase) levels were found to be abnormally high...

often an indicator of a heart attack, 

 after a few more blood tests over a month or so the levels were just going upwards, the doctor recommended I stop taking Simvastatin, and the CK level dropped too, my cholesterol level at present with no medication is 5.6, lower than My Doctor, who is in his mid 30's, he tells me his reading is 6.2 without any meds

if you Google Creatin Kinase and heart attacks there is a link apparantly between Taking Simvastatin and raised CK levels in some people

 

                                                                        Caveat Emptor

Edited by member 09 Sep 2015 at 16:55  | Reason: Not specified

User
Posted 09 Sep 2015 at 18:29
Interesting points raised, thank you everyone.

After last posting on this thread, we spoke to the GP who suggested coming off the statin for a few months to see if there was a reduction in aches and pains, which there has been.

However, considering the benefits that the statins promise, especially in terms of PC, my OH wants to try another brand, commencing shortly.

Just for information, our GP also said that you can take only 3 statins a week ( rather than every day) and get the same effect????? he suggested that this may reduce any related aches and pains for anyone suffering with them, or as something for people to try reducing the intake to see if it helps. As always I would suggest discussing this with individual GPs, as I have not heard this before.

best regards to everyone fighting this disease.

Alison

User
Posted 09 Sep 2015 at 22:14

I finished my HT in 2008 but a considerable time later was put on Simvastin to reduce cholesterol However, I didn't connect it but began to get cramps. I was prescribed Quinine Sulphate for this and it has helped. Think I will speak with my GP about a different statin and indeed discuss if a trial period without statins my help, if there is no benefit lost for PCa.

Barry
User
Posted 09 Sep 2015 at 22:24
Ref my post further up this thread my GP who specialises in cardiology and also works at a hospital 2 days a week asked me to take Co-Enzyme Q10 which I bought in Holland & Barrett, before prescribing another statin - rosuvastatin which so far I'm taking without any problems. He started me on 5mg and has just increased it to 10mg as I was ok with it.

Arthur

 
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