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Olaparib see today's news

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User
Posted 29 Oct 2015 at 17:54
In the news today ...... Let's hope this is a great sign for our men's future health ๐Ÿ‘๐Ÿ˜Š

This has been described as a milestone as it could also halt tumour growth I many men with treatment-resistant prostate cancer.

A third of 49 men had tumours that stopped growing, with numbers of circulating tumour class in the blood falling and PSA levels plunged by up to 96%

Full article on cancer research uk website link further down

A trial of olaparib for prostate cancer that has spread and has got worse after hormone therapy and chemotherapy (TOPARP)

Cancer type:

Prostate cancer

Status:

Open

A trial to see if olaparib helps men with prostate cancer that has got worse despite treatment with hormone therapy and chemotherapy drugs called taxanes. The trial is supported by Cancer Research UK.

Doctors can treat prostate cancer that has spread with chemotherapy and hormone therapy. But prostate cancer may stop responding to these standard treatments . Doctors are looking for new treatments to help men in this situation. In this trial they are looking at a drug called olaparib.

Every cell contains DNA. It is the genetic information that controls how cells behave. In cancer cells, the DNA is damaged and they rely heavily on an enzyme called PARP-1 to repair it.

Olaparib stops PARP-1 from working. If PARP-1 doesnโ€™t work, cancer cells canโ€™t repair themselves and they die.

Olaparib has been looked at in trials for other types of cancer, both on its own and alongside other drugs. The aims of this trial are to

See if olaparib helps men with prostate cancer that is not responding to hormone therapy

Find out if some men are more likely to benefit from olaparib than others

Recruitment start:

04/07/2012

Recruitment end:

01/04/2017

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief Investigator

Professor Johann de Bono

Supported by

AstraZeneca

Cancer Research UK

Experimental Cancer Medicine Centre (ECMC)

Institute of Cancer Research (ICR)

NIHR Clinical Research Network: Cancer

The Royal Marsden NHS Foundation Trust

Other information

This is Cancer Research UK trial number CRUK/11/029

http://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-of-olaparib-for-prostate-cancer-that-has-spread-and-got-worse-despite-hormone-therapy-and-chemotherapy-toparp

User
Posted 29 Oct 2015 at 17:54
In the news today ...... Let's hope this is a great sign for our men's future health ๐Ÿ‘๐Ÿ˜Š

This has been described as a milestone as it could also halt tumour growth I many men with treatment-resistant prostate cancer.

A third of 49 men had tumours that stopped growing, with numbers of circulating tumour class in the blood falling and PSA levels plunged by up to 96%

Full article on cancer research uk website link further down

A trial of olaparib for prostate cancer that has spread and has got worse after hormone therapy and chemotherapy (TOPARP)

Cancer type:

Prostate cancer

Status:

Open

A trial to see if olaparib helps men with prostate cancer that has got worse despite treatment with hormone therapy and chemotherapy drugs called taxanes. The trial is supported by Cancer Research UK.

Doctors can treat prostate cancer that has spread with chemotherapy and hormone therapy. But prostate cancer may stop responding to these standard treatments . Doctors are looking for new treatments to help men in this situation. In this trial they are looking at a drug called olaparib.

Every cell contains DNA. It is the genetic information that controls how cells behave. In cancer cells, the DNA is damaged and they rely heavily on an enzyme called PARP-1 to repair it.

Olaparib stops PARP-1 from working. If PARP-1 doesnโ€™t work, cancer cells canโ€™t repair themselves and they die.

Olaparib has been looked at in trials for other types of cancer, both on its own and alongside other drugs. The aims of this trial are to

See if olaparib helps men with prostate cancer that is not responding to hormone therapy

Find out if some men are more likely to benefit from olaparib than others

Recruitment start:

04/07/2012

Recruitment end:

01/04/2017

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief Investigator

Professor Johann de Bono

Supported by

AstraZeneca

Cancer Research UK

Experimental Cancer Medicine Centre (ECMC)

Institute of Cancer Research (ICR)

NIHR Clinical Research Network: Cancer

The Royal Marsden NHS Foundation Trust

Other information

This is Cancer Research UK trial number CRUK/11/029

http://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-of-olaparib-for-prostate-cancer-that-has-spread-and-got-worse-despite-hormone-therapy-and-chemotherapy-toparp

User
Posted 30 Oct 2015 at 01:00
This is the drug i have been talking about for a while . Its benfit is limited to certain types of PCA and that may necessitate DNA profiling which can be very expensive. However it is one of many that are now surfacing from years of biological engineering and targeted treatment therapies. The future can only get better!

Xx

Mo

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User
Posted 29 Oct 2015 at 20:23

Any news on the new treatment front has to be encouraging. This sounds very interesting!

User
Posted 30 Oct 2015 at 01:00
This is the drug i have been talking about for a while . Its benfit is limited to certain types of PCA and that may necessitate DNA profiling which can be very expensive. However it is one of many that are now surfacing from years of biological engineering and targeted treatment therapies. The future can only get better!

Xx

Mo

User
Posted 10 Nov 2015 at 10:04
Yes it's great news. I think the diagnostics side needs looking at too. We Wait latest MRI results but the consultant gave us a copy of the scans and having seen the ones for the previous MRI with the standard MRI machine - fuzzy, almost pixilated!! The recent scans are so clear, we remain hopeful using a superior MRI scanner we may have a clearer idea of whether biopsies are needed, or at least the exact area to be targeted, the scans are total gobbledygook to us, with untrained eyes but the clarity on the screen is amazing.

Let's hope they become standard soon, they could save a lot of worry let alone consultants appointments and related costs to pre op and unnecessary biopsies and possible complications ๐Ÿ‘๐Ÿ˜Š

 
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