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Action for Rising PSA?

User
Posted 14 Dec 2015 at 12:40

My husband was diagnosed in 2011 aged 44, PSA 242, Gleason 4+5, contained in Prostate.

Following RT and continued HT his PSA was at its lowest in January this year (0.16) but has risen steadily to 0.43 this month.  The advice I have received is that some specialists will intervene at PSA 2.16 and others will wait until it is much higher.  Does anyone have any thoughts or advice on this?  My husband doesn't have an appointment with his oncologist until Feb 2016.

Thanks 

User
Posted 14 Dec 2015 at 16:56

Hi Spaull,

You don't say if your husband is still on HT.

I also had RT and HT and my HT treatment lasted for three years. The HT treatment was stopped over 2 years ago and my PSA has since risen from undetectable to 0.4 ng/ml. I was told that the PSA would rise on stopping the HT and I am assured that my current PSA reading is not a cause for concern.

Additionally I have been told that treatment will only be offered if my PSA rises to 2.0 ng/ml. i.e. 2.0 plus my lowest level (effectively zero).

As far as I understand this is standard practice and as you suggest you can expect some intervention if you husband's PSA rises to 2.16 ng/ml

 

Tom

User
Posted 14 Dec 2015 at 17:22

Thanks Tom, I needed the reassurance.

 

My husband is still on HT and the oncologist has ruled out coming off of HT.

 

User
Posted 14 Dec 2015 at 21:26

In some hospitals, they only re-start treatment when the PSA reaches 10 or 20 - this is because the treatment would usually be to re-introduce HT which is then a pretty permanent feature. As your OH is already on long term HT, the game is slightly different and discussion would be about at what point to accept that the HT is no longer working and either add something extra or change to a different treatment. Either way this is likely to be at a much higher point than he is at the moment.

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 15 Dec 2015 at 05:10

Thank you for the advice.  It helps, I want to make sure I ask the right questions. 

User
Posted 27 Aug 2016 at 06:59

Just to let people know, Neil's PSA is at 2.2 and they are adding Bicalutamide to his existing Zoladex implants.  Having read through various posts this morning I am aware of so many different treatment paths and would be very grateful for any suggestions for questions I should bring up at the next appointment.  For example, I've read of people that have had additional scans but a specialist nurse advised a scan is only really necessary if it might change the treatment (but surely you need a scan to know this!).  I realise Neil's PSA is still low but I want to be prepared for the appointment. 

Edited by member 27 Aug 2016 at 07:51  | Reason: Not specified

User
Posted 30 Aug 2016 at 01:16

I am sorry to see this, spaull. Not sure that I agree with Heenan that 2.2 is not to be concerned about - the PSA doubling time is worrying, which is why they have added the Bicalutimide. Hopefully, Neil will see a drop at the next test.

It may be that 2.2 is too low for a scan to be worthwhile though - wherever the remaining cells are, they would have to make a pretty significant tumour to show up. You could ask whether a choline PET scan is available in your area, or enquire whether Neil could get on the trial of a new tracer which is more sensitive than choline.

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 30 Aug 2016 at 06:05

Thank you for the advice. To be fore warned is to be fore armed!

 
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