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Enzalutamide??

User
Posted 18 Dec 2015 at 15:43

Hi there everyone.  I haven't posted in a while but was after some advice.  My Dad finished (eventually) 10 sessions of chemotherapy last month and has seen the Consultant today for an update.

 

For those of you that have seen my posts before, mum and Dad are no the best at asking questions!!  The consultant today said that Dad would be off all forms of cancer treatment for the next 3 months and that in March, he will be started on Enzalutamide.

 

I have been looking this up and have come across that it is only given when chemotherapy has failed and that this is the next step.  Is this always the case because when I spoke to my mum earlier, she mentioned that the consultant hinted that he may be given further chemo in the future, but surely this wouldn't be done if it hadn't worked.  Up until October the PSA level was coming down but since then, no-one seems to know the most recent PSA.

 

Any more information would be greatly appreciated.

 

Many Thanks

Rachel

 

User
Posted 18 Dec 2015 at 16:44
Rachel

replying for you is like doing a jigsaw with some bits missing, I am sure you know what I mean when you can only get so much information off your Mum and Dad!

All I can tell you is that Enzalutamide is one of the newer drugs for PCa it took a while to get approval as all drugs do. It is commonly given when other Hormone based treatments have failed. It is also very common for it to be prescribed upon completion or even partial completion of Docetaxel chemotherapy.

I can only assume the 3 month gap is to give your Dad a breather and to allow him some time to regain some strength post chemo.

There are other chemo treatments that can be used later including docetaxel (which can be used more than once) if that is considered to be appropriate.

In advanced PCa, PSA is just one measure, most Oncologists would say that the most important factor is how your Dad looks and feels.

I hope this helps a little bit and I wish you and your family all the best for Christmas

xx

Mo

User
Posted 19 Dec 2015 at 09:51

Thank you very much for your reply Mo and yes, I know exactly what you mean about it being a jigsaw puzzle, they are very frustrating.  Everytime they have an Onco appointment, it always goes in the same way.  They make a list of questions they want to ask and then ask none of them!!  They didn't even find out if the chemo was deemed to have worked!!

 

I really appreciate your advice and help for this and would like to wish you and your family a very Merry Christmas too xx

 

Many thanks

Rachel

 

User
Posted 19 Dec 2015 at 10:59

Hi Rachel,

I had six months of chemo and did really well on it, but my onco still put me straight on to Abbi after chemo, please don't think the chemo has not worked.

I think the correct medical term for this is, throwing the kitchen sink at it.

Hope you have a great Christmas

Si x

Don't deny the diagnosis; try to defy the verdict
User
Posted 19 Dec 2015 at 11:33

Hello Rachel,
My husband Tony also has advanced Pca with multiple bone mets. Early this year he had a course of chemo (Docetaxel) which was aimed at prolonging the the time for which the cancer would respond to the hormone injections. This didn't seem to have much effect, as his PSA soon started to rocket back up. He was put on Enzalutamide, which seems to be becoming the standard next step in the treatment path.

So far, now in his second month of Enza, he's responding well, and feeling and looking well too. If it works (and some men respond better than others) we understand that this may buy him a better quality of life for perhaps 8 - 12 months. It's a way of postponing the more intrusive and unpleasant treatments. We are prepared for it to be less than this time, as Tony's cancer is very aggressive. We think the next step, when this fails, will be either Radium 223 or further chemo with Cabazitaxel (or possibly both in succession). Cabazitaxel is often given if Docetaxel is suspected not to have worked.

It really is quite difficult for anyone to say how much a particular treatment has helped, or what would have happened without it, so your Dad's lack of information on this is understandable. I do feel for you and your parents. These consultations are so stressful, especially if you are receiving news about how much longer you may have to live, and how and when you are likely to die. Even with a list of questions in your hand, it's easy to be a bit overwhelmed, especially if the oncologist says something unexpected.

Does your Dad have access to a cancer nurse? Even if he doesn't see one regularly, he probably has a phone number for one. One idea would be for your Dad to plan a phone consultation, or even a face-to-face chat, with a nurse, ideally a few days after an oncologist consultation, to discuss what they've been told and ask any further questions. Perhaps they might consider this in fhe New Year, to help get their heads around the likely options and treatments ahead.

I'm sure your parents appreciate your support and concern, but I'm also sure (speaking as a parent of adult children) that they will want you to live your life to the full and not weigh yourself down with worry on their behalf. I hope your Dad is well enough to enjoy the Christmas season and enjoy each day as it comes.

Marje

User
Posted 24 Dec 2015 at 10:37

Thank you everyone for all of your kind words.  I really appreciate all of the information and advice you have given me.  Mum & Dad won't speak to a cancer nurse unless in an emergency as I think that all the time the doctors aren't saying there's nothing more they can do, they are quite happy!!  

 

THe good news is that mum and dad managed to drive down to our house in Gloucester from Kent for a few days so I get to spend Christmas with him, which will be wonderful.  Seeing him has made me want to ask a few more questions though.  He has been suffering a bit with more tiredness, lots of swollen ankle etc and I wondered if this might be a side effect of coming off the steroids after the chemo.  I have tried doing a little research of the side effects but only seem to come up with sites thinking that Dad wants to enter the next Mr Universe!!!

 

One other, slightly unrelated question is that when I click on 'my conversations' in this forum, my most recent conversations aren't showing up.  Any ideas why this is happening??  Even this conversation does not show up.

 

Anyway, it's Christmas Eve and whatever the future has in store, I fully intend to enjoy the next couple of days with Dad and feel grateful that I get to spend this time of year with him.  I hope you all have a lovely Christmas, get some lovely presents, over indulge a bit but most of all to try and forget about the 'C' word for a while and have fun with your families.

 

Merry Christmas

Rachel

 

User
Posted 24 Dec 2015 at 11:06

I think my conversations shows those you have subscribed to, recent conversations will give you recent posts.

User
Posted 24 Dec 2015 at 13:30

Merry Christmas to you too Rachel. Enjoy this special Christmas with your dad and family.

I can't offer advice regarding your dad's condition as I just do not have that knowledge.. Even though it's Christmas Eve I hope somebody will be along to help

We can't control the winds - but we can adjust our sails
 
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