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Tamsulosin and PSA

Posted 20 March 2016 17:42:47(UTC)

Hello to any gents who have prostate cancer or are healing from treatment.

When talking about Tamsulosin my GP has twice now stated that it has an effect of lowering PSA.

However my urologist surgeon maintains that it does not.

I was wondering if any other gents have had similar conflicting information?

Thanked 1 time
Posted 20 March 2016 21:13:10(UTC)

Hi Beachy, I have been taking Tamsulosin since September 2014 and all it was supposed to do is help me with the frequent visits to the loo at night, I was going 9/10 times each night. After the first three months Nothing changed and I went back to GP whole gave some more and put me on Finesteride as well while at the same time sent me for a PSA test.

there may be someone on here that knows more about it and what it is supposed to do but I am sure it has nothing to do with PSA levels, I might be wrong but nothing has been told to me from my GP.

I would rather trust the urologist surgeon than a GP on this one.

Best wishes, Chris/Woody

Life seems different upside down, take another viewpoint

Thanked 1 time
Posted 20 March 2016 23:10:34(UTC)

Hi Beachy,
something was published about 4 years ago by I think the Royal Marsden saying that tamsulosin reduces PSA by about 50% - it is therefore important that GPs allow for this when deciding whether or not a man's PSA level is cause for concern. This is not to be confused with an idea that tamsulosin etc are good for controlling prostate cancer - more that they cause a false low.

So my understanding is that your GP is quite correct and I am surprised that the specialist is saying something different - perhaps there is some professional disagreement across the country or between disciplines?

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

Posted 21 March 2016 17:17:39(UTC)

Hello Beachy,

I too had contradictory advice on this. I believe the Urologist is correct and your GP is mistaken. As an example Clinical Advisor  

Tamsulosin is an alpha blocker and relaxes smooth muscles in the bladder neck and prostate.

(I believe the "50%" comment in post 3 is referring to 5-alpha-reductase inhibitors, Finasteride and Dutasteride.)

Hope this helps.



Thanked 1 time
Posted 21 March 2016 17:56:13(UTC)

Hi Beachy,

This is taken from the drugs.com website


"No laboratory test interactions with Tamsulosin hydrochloride capsules are known. Treatment with Tamsulosin hydrochloride capsules for up to 12 months had no significant effect on prostate-specific antigen (PSA)."


Hope this helps


Posted 21 March 2016 18:15:30(UTC)

Ah, sorry Beachy - Pierre makes a good point. I confused Alfuzosin and Tamsulosin :-#

Alfuzosin (Xatral) makes no difference to PSA

Tamsulosin (Flomax) reduces PSA in men that haven't got prostate cancer but has no effect on men with PCa

Finasteride (Proscar) and dutasteride (Avodart) reduce PSA by about 50%

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

Thanked 1 time
Posted 22 March 2016 19:58:52(UTC)

Thanks for the replies, I had concluded that it was the Urologist who was correct. I was interested to see that others had also received contradictory information.

It is unfortunate that misinformation is given out by the professionals, and pops up on forums. 

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