"The road ahead"!

Valleyboy, I'm a bit ahead of you in the cabi race, but following in Si's footsteps. Just completed my first cycle and found it comparable to my experience with docetaxel. First four or five days some nausea, for which domperidone wasn't a great help, then smooth sailing. Bloods seem to have been unaffected. Hope yours goes well.

AC

That's a lot of chemo, Dave. I wondered if you had been tested for DNA repair gene mutations? If you have one (about 20% do) you might be eligible for a trial of a PARP inhibitor drug.
Good luck!

Hi all
Just a quick update as I went for my 1st of 6 Cabazitaxel infusions yesterday and other than some lower back pain between 11pm and 1 pm last night everything else seems ok.
Infusions went in a similar order to my previous regime-saline drip, steroid drip, chemo infusion then saline drip. But this time they also added an antihistamine drip before the steroids?
The reason they’ve started me back onto another course of chemo is because my PSA back up to 322, form 128, (started in Feb/17 at 1547), so they’ve kept the Enzalutamide on the back burner at present and gone straight to a stronger chemo regime to try to knock it back a bit?
Home by 3 pm yesterday and took my new puppy for a walk, and I’m off out again with him around 10am this morning this time for his first experience of the beach.
With regard to ancillary tablets I’m back on Prednisone (2 a day) for 21 days and this time around I have to have bloods every week before my next infusion instead of just the day before when on Docetaxel. I’ve also been given Loperamide and Metoclopramide for use as required, none required yet??
As usual I ll keep you updated as to any significant changes otherwise I ll just update after next infusion.
All the best everyone, stay strong.
J

Thanks for the update. I do hope that this works for you with minimal side effects.
Best wishes

Ok just back from 2nd infusion of Cabazitaxel and as usual all went well and feeling ok.
As expected (after 1st infusion), my PSA has “spiked” back up to 711 ?? (From 311), However via my onco although concerning she wants to wait until next reading in 3 weeks time before taking any other action. As hopefully by then if the PSA starts to reduce then all ok, if not???
Anyway still feeling fine so just off out for a walk with the dog, and as for previous posts unless anything untoward happens I ll update you all again in 3 weeks.
Keep the faith
J.

Valleyboy, my experience (now in fourth cycle) is that PSA changes are much less dramatic than with docetaxel and start on the downward trend from your current cycle. I certainly hope that is true! You will need some big changes, though.

I hope you get them!

AC

Ok, back from 4th infusion of Cabi and all ok at mo. Played golf yesterday no issues and playing again tmos so tally-ho. PSA down another 7 points to 580 so not much to talk about but again moving in the right direction. Just had my usual afternoon nap and now I’m ready for anything!!😂 As long as it involves golf and footie on TV. !! “Keep the Faith” J.

Hope things continue to go well with the cabazitaxel.

I can’t answer your question about your alkaline phosphate but I’m sure someone who knows more than me will come along.

It’s a nice sunny morning where I am, hope it is where you are too, enjoy the golf.

Ian

Well it certainly suggests that there is less bone activity than before. Enjoy the golf :-)

So it’s a full CT scan for me on the 29th June, followed by a meeting with my consultant to see if, as my PSA has finally started to drop, wether she’s going to push me on for 10 infusions, or look at another treatment option? Any comments/ideas/experiences welcome.

Just an aside, also due my yearly Diabetes review next week and bloods for that have come back down to 42 so all good there then!,

Also lucky I didn’t have a drugs test when playing golf yesterday as I parred 8 of the last 9 holes!!😜🏌️

Keep the Faith

J.

IDO4.   Thanks for ur comments.    Wouldn’t wish pca  on anyone but after last weeks run of Pars, yesterday I scored 45 pts in a club comp (came 2nd!!), thus reducing my handicap by a further 2 shots!!  So that a 3 shot reduction in two weeks. No banditry here then!!😂

off for my annual diabetes clinic later but with my blood marker being 42 with <48 ok, I’m hoping it will just be more monitoring and no tablets today. 

Thank you for the update Valleyboy - I always read your posts with interest and wish you the very best with your ongoing treatment. 

Thanks. Just had chemo2/7 Cabazitaxel, and as usual all ok and completed in approx 3 hours.    just took another look at Trevor’s bio, and whilst it seems he coped ok with the radium treatment, he obviously had so many other things going on that they eventually combined to take him away. Still makes me sad thinking about it, but when you consider he started with PSA at app 13000, what am I moaning about 1547!😂

so if you do feel up to it (and don’t worry if you don’t), would you still recommend Radium 223 As a treatment option?  and what benefits if any did it give Trevor?

ps.

as I’ve already had Docetaxel and on Cabazitaxel chemo at the moment, (plus lifetime hormone injections), and as at the moment I’m still relatively healthy, still playing golf, walking, gardening etc. I m obviously going to take my oncos advise and take the radium. And then I’m still hoping there’s also a few other treatments in the “box” following this!

stay strong x 👍

Had a phone call today from both my onco’s specialist nurse here in Wales, and the radiography section in the Bristol Royal Infirmary stating that I’m due to start a course of 6 infusions, (1 per month ), from 10th August. So that’s no more chemo for me (at the moment), just completed 7 of 10 Cabazitaxel infusions but my PSA remains high at 542.

Also they’ve agreed that I can have my bloods and a clinic visit about 10 days before each infusion here in West Wales. Which means I only need to travel to Bristol once a month which is great. Evidently Treatment will take about one hour from arrival to discharge, so it’s also much quicker than a chemo infusion?

Done a bit of background reading about Radium 223 and it seems as if my PSA Reading will not be as important a marker on this treatment as my general health and well being combined with bone pain relief. However, as I explained to Bristol this afternoon, to be fair at the moment my bone pain is minimal, and I’ve been painting, strimming and trimming bushes today!! With Golf planned for tmos and Saturday!

So as I embark on yet another treatment journey I ll endeavour to keep you all up to speed on my progress over the next 6 months.

Keep the Faith

J.

Thanks from a Celtic Warrior!!

Sorry to see that your PSA has remained high but some on here have had great results with Radium 223 and less travel will be a blessing. Fingers crossed for you.

Dear ValleyBoy, See my thread “Medical science, progress and hope” where I post interesting new stuff. They are also keen on the PSMA targeted approaches.

Edited by member 27 Jul 2018 at 08:57  | Reason: Not specified

Just like to mention that I couldn’t have been given a warmer and more professional welcome by all the staff in Bristol Oncology unit, proving that the NHS treatment I’m receiving in both Carmarthen and Bristol is second to none. Well done to all concerned.

ps. Golf already planned for tmos morning, followed by Swansea’s 1st home game in the Championship at 3pm. 🙈😂

You sound quite positive Valleyboy. Keep golfing. I am too!

wishing you all the best.

Ian

Played golf this morning, then went to watch the “Swans” beat Preston. Then popped in the local Rugby club on my way home for a few “Becks Blue” and a salad roll, and yes I am the only one down there drinking it!!😜

Bit tired now so having and early night, but as we ve been awake since about 5 am with the puppy it’s not really that early is it!?😂🐶

Keep the Faith

J.