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What next Docetaxel ?

User
Posted 15 Aug 2017 at 20:11

Hi to everybody at Prostate Cancer UK and all the other organisations such as Tackle and all the regional groups up and down the country. Everybody out there is doing a great job . I decided that I would share my experiences with other men who may be in a similar situation as myself . I was diagnosed in November 2013 just after my 60th Birthday , which is almost  4 years ago with a PSA level of 222 . A scan about a month later showed the Cancer had spread to my Lymph Nodes ,  I was told it was Stage 4 and so a steep learning curve on all matters to do with Prostate Cancer began . I started with Bicalutamide plus the 3 monthly Zoladex injections , my PSA came down very rapidly but when they started to rise after about 2 years, I started on Enzalutamide ( Xtandi ) as well as the Zoladex . A scan had also revealed that the Cancer had spread to my bones and was in my Lower Spine , hip , ribs , shoulder and skull  . But my PSA levels had started to come down once again so hopefully slowing down the spread and further growth of the Cancer .  The problem I had with Enzalutamide was the tiredness . It was ok at first but after 6 months I felt completely wiped out however I persisted as my PSA was coming down steadily again and was now approaching single figures . At this point my Consultant thought we should reduce the Enzalutamide from 4 tablets ( 160 mg ) to 3 to 2 over a period of a few weeks in a effort to stop feeling so tired .  3 months ago my PSA went as low a 1.4 and I was even feeling less tired than I had in a long time .  On my next vist to collect my tablets my PSA was 4 so it was decided to go back to the 4 tablets . It was also decided that I should have 2 scans , a Bone Scan and a CT scan . Fast forward to today and my PSA is 15 . I see my Consultant  in 2 days time to get the results of my scans . I fully expect to go onto Chemo ( Docetaxel ) due to the discussions I had with my Consultant 6 weeks ago . I understand that I will have 10 sessions at 3 weekly intervals . The Consultant hasn't really discussed what comes next although doing my own research Cabazitaxel may follow . I still remain optimistic about the future but somewhat cautiously . Nearly 4 years in I know that I can't do anywhere near what I could , I've lost a lot of my strength due to the side effects of the treatment as well as the tiredness that I mentioned earlier . I can discuss everything with my wife and my 2 sons and this has really helped all of us . My youngest son comes with me to all my appointments and has become a bit of an expert himself on all Prostate matters . They will at least know to get checked themselves when they are a bit older which sadly is something I didn't do . 

I will post an update in 2 days time with the results of my scans . 

Thank you for reading this and good luck to everybody who is receiving or about to receive treatment . 

Ron Marston 

 

 

 

 

 

User
Posted 16 Aug 2017 at 06:18

Ron,

My profile is very similar to yours, click on my picture to see it. If you want a blow by blow account of what Docetaxel was like for me then click here:

http://community.prostatecanceruk.org/posts/m152388-Docetaxel-Chemo---the-highs-and-the-lows#post152388

I hope it will help you prepare yourself for Docetaxel.

User
Posted 16 Aug 2017 at 16:53

Ron, you may be wrong to assume that further chemo would follow docetaxel. A period on steroids seems to be the current fashion. Also, don't assume you will necessarily have 10 cycles of docetaxel. It all depends on how you react to the treatment. In my case, I seemed to get full benefit out of six cycles, by which time the blood clots raised as a possibility when I signed the consent form, had materialised, in my lungs. A serious complication! Watch out for breathlessness and don't assume that it is necessarily a passing phase, perhaps related to fluid retention, as I did.

Certainly, the early cycles of docetaxel, I found easy to take, as I think most men do. Good Luck with your adventure down this track!

AC

User
Posted 19 Aug 2017 at 07:51

Hi David - Thanks for your reply . I found the idea of iced pineapple intriguing 

I saw my consultant on Thursday and instead of going onto Chemo or Radium 223 which was also a possibility I have gone onto a Drug 

called Diethystilbestrol - its another hormone therapy which was used before the intoduction of drug such as Enzalutamide and Arberitone .

So in the short term no pineapple for me and I get to keep my hair for a bit longer !!

My Consultant is also arranging for me to see specialists at The John Radcliffe

Hospital in Oxford and The Royal Marsden in Sutton  ( Surrey ) . My PSA was up to 19 so it will interesting to see if it goes up or down 

with the new drug . 

Were all in this mess together so its good to get as much infomation as we can from fellow sufferers . 

Keep up the good work and let me know how your doing . 

Thanks 

Ronnie 

 

 

 

User
Posted 19 Aug 2017 at 08:18

A few members here have had Stilboestrol and done well; look up Devonmaid whose husband has had a remarkable response for many years. Also you may find additional info on Harmony or Aldee's profiles.

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

 
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