Hi all,
My father in his 80's has had prostate cancer for six years. Earlier this year he was diagnosed with advanced prostate cancer which has spread to the bones. He was at this time given zytiga. At the time the Zytiga was commenced, his PSA reading was mid 90's. After the first month's treatment ( bloods taken three weeks after commencing drug) the count had dropped to around 30. Obviously we were delighted, however the bloods taken prior to end of the second month produced a PSA reading in the hundreds.
Infection has been discounted as a cause, however I noted clinical data from Italy earlier this year reported a PSA spike in some patients on zytia. What is unclear to me is whether such a huge jump could be a spike, which may resolve if given more time on the drug, or if it is more indicative of something else at play. I wondered if anyone had any thoughts on this.
Thanks in anticipation :)