Thank you for your comments and link to the review
Of course I do not agree with their conclusion or even the methodology they had to make them. They compared several polyphenol rich extracts mostly with small phase two studies. They only included two RCT - the Pomi-T study and Pomegranate extract - both, especially the pomi-T were statistically significant with a p value of <0.0001 which means a less than in in a 10000 chance that the results where not real - a 64% change in PSA dynamics - so they are incorrect as well as misleading. You many know there was a later trial which also correlated PSA with underlying MRI changes
Their, yet to be fully published, review should have just included RCT then their conclusions would be very different
That said, clearly we need more research in this field which the Pomi-T endeavoured to achieve and so far it the most clinic robust research - hopefully more to follow
There is actually a number of RCT (not mentioned in the review) on Lycopene, saw Palmetto and soya all of which, as you say were negative. More worryingly direct antioxidant vitamin A and E supplements may actually be harmful.
In my experience both clinically and on the research side I am total convinced that lifestyle and nutrition have a major part in the development and progression of cancer. Of course, exercise, getting enough vitamin D, reducing process sugar, protecting your mood also play a part to support dietary interventions (more)
A double blind, placebo controlled randomised trial (RCT) evaluating the effect of a polyphenol rich whole food supplement on PSA progression in men with prostate cancer - The UK National Cancer Research Network (NCRN) Pomi-T study. R Thomas, M Williams1, H Sharma, A Chaudry, P Bellamy. Prostate Cancer and Prostatic Diseases March 2014 17, pp180-6 (doi:10.1038/pcan.2014.6)
Prostate Cancer Progression Defined by MRI Correlates with Serum PSA in Men Undergoing Lifestyle and Nutritional Inter- ventions for Low Risk Disease Thomas, Muhammad Shaikh,5 Michael Cauchi, and Dorothy Daiyi Yang J Lifestyle Dis Management. 2015 01 01