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Medical science, progress, and hope

User
Posted 02 Mar 2018 at 20:39

Have a look at this news item from Prof de Bono and the Institute of Cancer Research:

https://www.icr.ac.uk/news-archive/men-with-incurable-prostate-cancer-living-twice-as-long-as-decade-ago

 

User
Posted 02 Mar 2018 at 20:39

Have a look at this news item from Prof de Bono and the Institute of Cancer Research:

https://www.icr.ac.uk/news-archive/men-with-incurable-prostate-cancer-living-twice-as-long-as-decade-ago

 

User
Posted 03 Mar 2018 at 14:28

The Prof was Spurspark’s consultant and much of the testing and trialling that Spurspark was willing to put himself through (including being the first person on here to take Abbi) is benefitting current members more than they could ever imagine.

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 19 Jul 2018 at 18:21

This is interesting. The drug in question is already used widely for autoimmune disease.
https://www.icr.ac.uk/news-archive/immunotherapy-drug-for-skin-disease-could-boost-hormone-treatment-for-prostate-cancer

Edited by member 19 Jul 2018 at 18:24  | Reason: Not specified

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User
Posted 03 Mar 2018 at 12:24

Hmmm.

 

It's five years old, and just the views of one man - but yes, we are living in a time of great progress, no doubt about that!

.

-- Andrew --

"I intend to live forever, or die trying" - Groucho Marx

User
Posted 03 Mar 2018 at 12:59
Five years old indeed, which means it includes abiraterone and enzalutamide as trial drugs. The paper that it is based on is far more than just views though, it is solid evidence and statistical analysis.
User
Posted 03 Mar 2018 at 14:28

The Prof was Spurspark’s consultant and much of the testing and trialling that Spurspark was willing to put himself through (including being the first person on here to take Abbi) is benefitting current members more than they could ever imagine.

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 19 Jul 2018 at 18:21

This is interesting. The drug in question is already used widely for autoimmune disease.
https://www.icr.ac.uk/news-archive/immunotherapy-drug-for-skin-disease-could-boost-hormone-treatment-for-prostate-cancer

Edited by member 19 Jul 2018 at 18:24  | Reason: Not specified

User
Posted 19 Jul 2018 at 19:57

Hi Dark warrior 

thanks for posting this interesting article. I completed 6 infusions of Docetaxel by August last year, however as my PSA had gone back up by Feb this year I re started a course of 10 Cabazitaxel in March. I’ve had 7 so far with no real ill effects ( still golfing, gardening, walking etc), with No 8 due on the 1st Aug. However PSA not reducing as much as when on Docetaxel so I’m off up to Bristol on Monday for a consultant clinic re-Radium 223. So it looks as if 5 years on from your article I’m following a similar path? Let’s hope it doubles my survival time too?!

Keep the Faith

J..

User
Posted 19 Jul 2018 at 22:25
Keep the faith indeed. In 5 years time there will be many new treatments available. I am thinking of PARP inhibitors for those with DNA repair mutations; PSMA targeted radioisotopes; and Immunotherapy working on a bigger percentage of patients than it does at present.

I wish you the best of luck with your treatment!

User
Posted 27 Jul 2018 at 15:21

Another novel approach to castration-resistant PC treatment:

https://labiotech.eu/medical/cellcentric-prostate-cancer-epigenetic/

User
Posted 02 Aug 2018 at 18:43

This is a nice summary of bipolar androgen therapy (BAT) by Sam Denmeade, the doctor who invented it:

http://www.hematologyandoncology.net/archives/june-2018/bipolar-androgen-therapy-in-the-treatment-of-prostate-cancer/

It's particularly interesting that in a trial for checkpoint inhibitor immunotherapy, both of the patients who responded very well had previously been through BAT. Dr Denmeade is now proposing to trial this combination. He's at Johns Hopkins in Baltimore, USA.

 

User
Posted 22 Sep 2018 at 18:32

This recent paper shows remarkable results in metastatic PC using targeted alpha therapy, 225-Ac-PSMA.

https://www.ncbi.nlm.nih.gov/pubmed/30232539

The study was done in South Africa. I know that this treatment originated in Germany, but I don't think it's available yet in Britain, unfortunately.

 
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