As you asked I will summarise although you can read my histology by clicking on my Avatar profile and bio, or by doing this for anybody else you want to check on as most people detail their histology in this way because what they say in threads tends to be lost over time.
My PSA was stable for about 2 years after RT treatment but then began to increase slowly but persistently thereafter. This is not greatly surprising as there remains some good cells within the Prostate. However, towards the end of 2014 my PSA had climbed to 1.44 and my consultant felt that the way it had progressed indicated there was some new or residual cancer in the Prostate which was confirmed by MRI. I was then referred to Prof M E at UCLH and after more tests and scans was accepted into a trial providing salvage treatment (HIFU or Cryotherapy as appropriate - the former in my case) , for failed RT. Please note that biochemical failure is normally considered to be the case if PSA reaches 2.0 plus the patient's nadir. I had the HIFU in July 2015 by which time my PSA had reached 1.99 so before the usual threshold. After the procedure it went down to 0.39 but has again slowly risen and as PSMA scan (done privately) showed small amount of cancer, I hope will be eradicated with some further focal therapy to the prostate. Also note that it is not usual to give focal treatment if the cancer is outside the Prostate.
However, initial RT can work for a shorter or very much longer time or forever, it depends on many factors, so my case is not necessarily very typical. Be aware that it often takes many newer forms of treatment years before being generally adopted by the NHS, although some of them become available earlier privately or abroad where patient's PCa may be treated more aggressively.
Edited by member 05 Jul 2018 at 19:29
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