Funnily enough, I raised the possibility of coming off Zoladex after 11 years with my oncologist a couple of days ago. He said he knew of no evidence on the pro and cons for cases such as mine. I suspect this is because I have outlasted the data! The argument seems to be - if the side effects are tolerable, stick with it as other treatments (currently none approved by NICE!) will have a cumulative effect. For me the side effects are zero sex drive (not bothered about this at 75!) and flab at the front between my hips and navel. I suppose decreased get up and go is also an effect, but I don't know how much more energetic I would have been without the Zoladex. Maybe very little! My PCa is castrate resistant, PSA only 0.9, but likely to rise without further treatment, no known mets, beyond one which may be a mothership remnant rather than a met in my urethra (bladder and prostate removed 6 years ago) which adds to my doubts about carrying on with it. If I'm honest, I lack the courage to take the risk of coming off Zoladex. It would help me and I suspect Kate's husband if anyone could point to any survey or trial data to inform our decisions.
AC