Hello Law, what an incredibly complex gland the prostate is. I confess I haven’t heard of sclerosing adenosis until I read your profile. It appears it is a benign condition.
I found an article which included a short section on this. See below.
“Sclerosing adenosis of prostate is very similar to that of breast. It is a benign lesion with the hyperplasia of both small acini and fibrous stroma. The lesion presents as nodular with well-defined boundary, but without capsule (27). Its histological feature is that the variable sized or shaped glands disorderly embed into prominent sclerotic stroma (Figure 2G). There are both clear secretory cells and amphophilic basal cells in the hyperplastic glands. Besides, some glands are surrounded by a layer of thick and eosinophilic basement membrane-like matter. The cells may have prominent nucleoli and intraluminal acid mucin. Sclerosing adenosis should be distinguished from small acinar adenocarcinoma. In IHC staining, the basal cells are not only positive for HMWCK (e.g., 34βE12, Figure 2H), CK5/6 and p63, but also positive for smooth muscle actin (SMA) and S-100 protein, which suggests those cells have myoepithelial differentiation (28,29).”
The full article can be found here
Having also read about testosterone reference levels it states between 10 and 27 is normal and that this should be measured between 8 and 10 a.m. as this is when T levels are highest.
I have no experience of TRT, because I am on HT I will be at castrate level of T.
Hopefully others will come along and answer too.
All the best.