I have only just started visiting the site for support again. My husband has been fighting the fight for some 10 years now! (we had cake with the Oncologist!) We have been treated by THE MOST AMAZING staff at the Clatterbridge Cancer Centre. My husband has had every treatment available including Radiotherapy, Abiraterone, Docetaxel, Cabazitaxil and more recently Enzalutamide. For those who may not know, there is a trial called Re-AKT which is a double blind trial using Enzalutamide together with either a placebo or another drug. Dave's PSA reduced from over 4000 to 700 in the space of 13 weeks and his alkaline phosphatase levels are back into normal levels from 400+ to 99. These are brilliant results but unfortunately due to a recent CT scan showing a couple of new lesions, he has been removed from the trial. This is devastating and we are looking at trying to obtain the drug on the NHS or some other way but the NICE protocols seem confusing about whether it is possible. Any response to this would be appreciated, but if nothing else, I wanted to say for all of you out there, not to give up hope, Dave has continued to respond to various treatments and is still here. We know we are getting close to the end of the line, but it's not over yet!!