I have been on enzalutamide now for 51 months.
I too started with abiraterone as well as enzalutamide plus the Prostap.
The abiraterone gave me terrible stomach and my ALT started sky rocketing so I came off it after about 2 months.
I've had no other medication than the enzalutamide and Prostap.
My psa started at 235 and dropped quickly to .05 where it has remained ever since and is where I am today.
Side effects is the usual and is handleable
I used to run but now hike/walk 3-8 miles twice a week.
Yes I get a bit more fatigued but such is my new life
I hope this helps a bit