PNI identified post-op is apparently so common that it hardly seems significant - the old thinking was that it indicated a higher risk of recurrence. PNI identified at biopsy is less usual and needs some consideration as it may be that there is more cancer than the other cores suggest. But again, the introduction of mpMRI means that cores taken are more targeted than in the past so a sample that shows PNI can be triangulated with the detailed analysis of the scans, etc., before treatment options are recommended.
John was diagnosed as T1 but with PNI and the surgeon's view was that there was a 55% chance of recurrence post-op. Once the prostate was in a petrie dish, the PNI turned out to be a reliable indicator as the cancer was much more extensive than predicted and he was upgraded to T3. He also had a recurrence and needed salvage RT/HT. But that was all before mpMRI was introduced.