I did read the paper in your link and others before it.
If you consider men with early stage PCa, most are unlikely to die due to it within 5-8 years regardless of what treatment they have or indeed no treatment. But in the longer term many of those treated would have had their cancer knocked back if not eradicated so it would be interesting to make these comparisons in 15-20 years time to be able to make more meaningful comparisons.
I would just emphasize a few things which among all the plethora of data in reports and trials may not be taken on board as regards Focal Therapy. It is only used to treat what is/are considered to be significant tumour(s) within the Prostate leaving any insignificant ones untouched. In time, one of these 'insignificant' tumours may become 'significant' or a new tumour may start in another part of the Prostate. Certainly in the case of HIFU, the procedure can be repeated if the tumour is accessible and calcification is not an obstacle. Where the cancer is too great to be dealt with by further HIFU, a Prostatectomy or Radio Therapy can be done. (I am not sure about whether salvage Prostatectomy or RT can be given after Cryotherapy but this would be something for anybody contemplating this procedure to ascertain).
Focal therapy is generally given only to men with early stage PCa where the cancer is Prostate contained, the volume low and the ablation treatment considered appropriate. The therapy can also be given as salvage treatment for failed RT.
There are other forms of Focal Therapy, some of which are only available abroad or in trials but the main ones in the UK are HIFU or Cryotherapy, where side effects are milder than Surgery or Radiation .
Edited by member 25 Apr 2021 at 22:11
| Reason: correction