You are correct that cryotherapy and HIFU are usually administered to men with less advanced and certainly the latter at least for failed RT. In fact when I had HIFU within a study for failed RT the surgeon who did the procedure said it was not done for more advanced Pca. Therefore,I am not surprised there is little on this. Certainly, side effects with focal therapy seem mostly to be quite mild but whether this remains the same and as effective with more advanced cancer will be some of the questions the Atlanta trial should answer. Of course, when the boundaries are widened for a treatment, it is going to take quite some time for results and experiences to be analysed and conclusions reached in the short to long term. A man taking part in trial such as this has to accept he is participating in breaking new ground which may or may not work for him.