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Tadalafil to Sildenafil oops Tad daily

User
Posted 05 Jul 2021 at 19:53

Tadalafil to Sildenafil or more correctly now Tadalafil 5mg daily.

It's been, I'm pleased to say, a long journey. Only tried Tadalafil a few years back. Got to the stage it failed time and time again so thought it's an age thing, so I gave up. Phone call from GP after e- consultation suggests I try daily Sildenafil, think 5mg was mentioned. We see how it goes.

Ray

Edited by member 07 Jul 2021 at 09:27  | Reason: Not specified

User
Posted 06 Jul 2021 at 10:07
Hi Chris, it really is good to read you're still here and fighting on - keep that attitude going. As regards injection, at my age not for me, but dont let that put other folks off trying it 

Ray

User
Posted 06 Jul 2021 at 21:28

Unfortunately, all the PDE5 inhibitors can cause acid reflux. This is because the esophagus and lower esophageal sphincter also use PDE5 to contract their smooth muscle, and the PDE5 inhibitor will prevent them contracting as tightly, and may allow acid reflux. It tends to only happen in those liable to acid reflux anyway. The half-doses (2.5mg or 10mg) of Tadalafil will often avoid this side effect, and may still work well enough to improve ED.

Something else that might make this effect worse is breaking tablets. All the PDE5 inhibitor tablets are film coated to help prevent direct contact between the PDE5 inhibitor and esophagus, and you break that film if you snap the tablets, which might make acid reflux worse in some people.

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User
Posted 06 Jul 2021 at 01:33
Fingers crossed for you Ray - if not successful, ask for Levitra next; it seems to work better for John than any of the others.

And also, how great to see you are still here & well x

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 06 Jul 2021 at 08:12
What an amazing run Ray. You could always bite the bullet and buy some Invicorp25 injections and get guidance. No where near as daunting as you think sticking a needle in the old fella. And the results back then were amazing. Good luck

If life gives you lemons , then make lemonade

User
Posted 06 Jul 2021 at 10:06
Hi Lyn, thanks. Likewise knowing both you and John ok.  Times so different now on ED help. Newer members perhaps don't realise at my time of diagnosis ED was, putting it politely, tough luck - end of conversation. However I have to say this GP has been very helpful.

Ray

User
Posted 06 Jul 2021 at 10:07
Hi Chris, it really is good to read you're still here and fighting on - keep that attitude going. As regards injection, at my age not for me, but dont let that put other folks off trying it 

Ray

User
Posted 06 Jul 2021 at 18:24

Sildenafil is available in 25mg, 50mg, and 100mg doses.

Urology/Andrology often start at max dose, which isn't how drug dosing is normally tried. When asked why, the answer was they don't want to spend weeks trying different doses to find the one that works - it' important to resolve ED as quickly as possible for mental health. If a given dose works, then you can try reducing to see if that also works. Reducing in the case of unacceptable side effects is another possibility.

There's also a 20mg Sildenafil, but that's intended for treating pulmonary hypertention (the original purpose of Sildenafil). It's a mixture of standard immediate release Sildenafil and slow release Sildenafil, and is intended for dosing at 3 times a day to achieve continuous dosing. I have come across one case of surgeon prescribing it for penile rehabilitation after prostatectomy (but probably not 3 times a day!). I think it was because the local CCG wouldn't prescribe Tadalafil.

User
Posted 06 Jul 2021 at 20:39
Thanks

A bit of background to all. Tadalafil taken 3/4 days after first dose might have just worked. However 2 pills a week created too much reflux and I'm 100% determined to keep off meds for that even if it means no erection.

Pill will not be for a one off event but a daily dose as its felt stomach should cope with that and provide erections. I note 5mg is available for pulmonary.

We see what pharmacy provide.

Ray

User
Posted 06 Jul 2021 at 21:17
Yeah, definitely a bit of confusion here - there isn't a 2.5mg or 5mg tablet of Sildenafil / Viagra for penile rehabilitation so I think the GP has muddled up Sildenafil (Viagra) and Tadalafil (Cialis)?
"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 06 Jul 2021 at 21:28

Unfortunately, all the PDE5 inhibitors can cause acid reflux. This is because the esophagus and lower esophageal sphincter also use PDE5 to contract their smooth muscle, and the PDE5 inhibitor will prevent them contracting as tightly, and may allow acid reflux. It tends to only happen in those liable to acid reflux anyway. The half-doses (2.5mg or 10mg) of Tadalafil will often avoid this side effect, and may still work well enough to improve ED.

Something else that might make this effect worse is breaking tablets. All the PDE5 inhibitor tablets are film coated to help prevent direct contact between the PDE5 inhibitor and esophagus, and you break that film if you snap the tablets, which might make acid reflux worse in some people.

User
Posted 07 Jul 2021 at 09:29
So its Tadalafil 5mg  Sildenafil was certainly mentioned. Perhaps GP thought I might have side effects issues so changed to Tadalafil daily - the bit I probably missed. Sorry for confusion - it's an age thing.

Re comment on coating of pills. Reflux was so troublesome at times the tablet just used to get stuck in my throat  no amount of water, or coughing would dislodge it then sone time later up it came half gone.

So I see how it goes

Ray

User
Posted 07 Jul 2021 at 10:29
Yes, I’d never heard of daily Viagra. The 5mg tabs of daily Cialis are quite small, so if you have them, bite one in half and take the halves with a pint of liquid.

I do that with my daily Allopurinol which are giant tablets for me.

How these drug smugglers swallow up to fifty condoms full of cocaine is beyond me. Perhaps they were all sword swallowers before their involvement in the drug trade!

User
Posted 08 Jul 2021 at 08:56

Rather than biting them and breaking the film coating, eat something afterwards to make sure it's gone all the way down, like some bread. PDE5 inhibitors do slow down swallowing because of inhibiting the PDE5 which is also used in that process, and can result in food being left in your esophagus.

 
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