There are no new drugs in the range of GnRH Agonists. Most (possibly all) of the side effects are due to very low Testosterone levels, and that is still the mainstay of systemic treatment.
There are a couple of potential new hormone therapy drugs on the horizon.
∙ Relugolix is a GnRH Antagonist, similar to Degarelix/Firmigon, but in daily tablet form. I don't suppose its side effects will be any different, although the recovery time after stopping is faster.
∙ Estradiol is an estrogen used to block Testosterone, in the form of a skin patch. This is currently being trialed as the PATCH trial. Estrogenic hormone therapy drugs can avoid some of the common hormone therapy side effects such as hot flushes and osteoporosis.
What is new is that if you start to become castrate resistant (switching off Testosterone stops working), there are now more extra drugs which can be added in to make the hormone therapy effective for longer, although you don't come off Zoladex (or whichever one you're on).
Also new is that in cases of advanced prostate cancer where you've already had radical treatment to the prostate, but now have up to 3 identifiable mets, you might be able to get some targeted treatment for them with curative intent. The cure rate isn't high, but even when it doesn't cure, it usually gives you additional time which might be free of hormone therapy.