I'm interested in conversations about and I want to talk about
Know exactly what you want?
Show search

Notification

Error

Brachytherapy - experiences and results

User
Posted 10 Mar 2022 at 06:20

We are meeting the oncologist fairly soon and would like some more info on Brachytherapy as in


are you happy with the result?


Any particular problems (ED, Incontinence)


Did you have to have HT?


Any other side effects?


Any advice is gratefully received.


Thank you


Main reason for asking is our local hospital does not offer it, the nearest is the Christie in Manchester about 2.5h drive so would like to know if it is worthwhile to travel that far.

User
Posted 10 Mar 2022 at 17:44

There are two type of brachy High dose rate or low dose rate: HDR and LDR for short. LDR is also known as permanent seeds brachy. HDR is often given in conjunction with EBRT and most likely with HT as well.


I had the HDR and the associated treatments. 


My PSA is now 0.1. I was much higher risk than your husband at diagnosis, and four years later I am probably cured. No one knows if they are really cured, and current statistics still say I'll be dead in about 15 years, but each year I'm cancer free pushes that date further down the line.


No incontinence.


ED bit of a problem, still working on solving this, it isn't too bad but it isn't what it used to be.


No other side effects post treatment, but two years of HT isn't great.


I was treated at the Christie. I was very happy with the treatment. I wouldn't be worried about a 2.5 hour drive for the brachy, or the six monthly follow up appointments (which they would probably do by phone). I had 15 sessions of EBRT, now I wouldn't have enjoyed three weeks of five hours a day driving. You may be able to have the EBRT element done locally if it is needed. As you won't be going on the trans Siberian railway any time soon, you could book a three week holiday in Manchester, or perhaps rent a cottage in Cheshire.

Dave

User
Posted 10 Mar 2022 at 21:26

The most common type of brachytherapy is the seed/permanent/LDR brachytherapy, where radioactive seeds are inserted which deliver the dose over about 200 days (in the case of Iodine125), after which they have become too weak to have much more effect. The dose is front loaded, and gets weaker as time goes on. This is usually given by itself or with hormone therapy, depending on the risk of the cancer, and depending a bit on the oncologist doing it.


The other type is temporary/HDR brachytherapy, where a single much more powerful seed is inserted for about 10 mins and then taken out, and the treatment is finished when you go home. However, a single HDR brachytherapy session doesn't work well as you need multiple radiotherapy sessions (or a long one as in the case of LDR) to be effective. Originally, 4, or 2 HDR sessions were done, but much more common in the UK today is that one HDR session is given, and the other is swapped for a half dose of external beam radiotherapy (known as HDR Boost). This is usually also given with hormone therapy (mainly for the benefit of the external beam radiotherapy).


The combination of HDR/external beam/hormones is good for high risk patients up to T3b. LDR brachy tends to be used for lower risk patients G3+4, T2N0M0, but can go up to T3a in some cases.


I had HDR Boost, and 2½ years later, I'm at the tail end of recovery and everything is working, except ejaculations are mostly dry (as expected). So far, I'm pleased with the result and in a much better state than I imagined at the outset. It will be another year or so before I know how successful the treatment was, but it's looking good so far. However, I'm aware I was a high risk patient, with perhaps a higher chance of recurrence.

User
Posted 11 Mar 2022 at 07:21
Not everyone gets hot flushes during HT; I didn't. I didn't find HT too unpleasant at all. Fatigue was the most noticeable side-effect for me.

The reason for HT is that it prevents the cancer cells from dividing while the radiation kills them. The radiation damages the DNA of all the cells in the vicinity; healthy cells can repair their DNA but in cancer cells this repair mechanism is usually faulty so the cell will eventually die, but this can take up to 18 months to happen. The HT holds the cancer in check while it gradually dies.

Best wishes,

Chris
User
Posted 11 Mar 2022 at 12:28

Hi,


I had PSA 2.19 and Gleason 3+4=7 and 5 cores out of 20 positive all contained within the prostate.I had the choice of Robotic surgery and Brachytherapy and after reading up about possible side affects i went down the Brachytherapy Low dose inplant route as i felt it was less invasive. I had the procedure in Mount Vernon London and was in for two days and apart from slight discomfort and regular trips to the bathroom all was well.I was given pain killers and used very few of them and laxatives that i never used ,Also had  Tamulosen that i took for six months and decided i did not need them anymore. ED was a problem and still is and i was prescribed  4 Viagra per month.


I had my Brachytherpy in September 2016 with PSA 2.19 and after six years with no incontinence or other real side affects i was signed off by my Specialist in January 2021 with PSA 0.05.


If you click on my Avatar you can follow my journey.


John.

Show Most Thanked Posts
User
Posted 10 Mar 2022 at 17:44

There are two type of brachy High dose rate or low dose rate: HDR and LDR for short. LDR is also known as permanent seeds brachy. HDR is often given in conjunction with EBRT and most likely with HT as well.


I had the HDR and the associated treatments. 


My PSA is now 0.1. I was much higher risk than your husband at diagnosis, and four years later I am probably cured. No one knows if they are really cured, and current statistics still say I'll be dead in about 15 years, but each year I'm cancer free pushes that date further down the line.


No incontinence.


ED bit of a problem, still working on solving this, it isn't too bad but it isn't what it used to be.


No other side effects post treatment, but two years of HT isn't great.


I was treated at the Christie. I was very happy with the treatment. I wouldn't be worried about a 2.5 hour drive for the brachy, or the six monthly follow up appointments (which they would probably do by phone). I had 15 sessions of EBRT, now I wouldn't have enjoyed three weeks of five hours a day driving. You may be able to have the EBRT element done locally if it is needed. As you won't be going on the trans Siberian railway any time soon, you could book a three week holiday in Manchester, or perhaps rent a cottage in Cheshire.

Dave

User
Posted 10 Mar 2022 at 21:26

The most common type of brachytherapy is the seed/permanent/LDR brachytherapy, where radioactive seeds are inserted which deliver the dose over about 200 days (in the case of Iodine125), after which they have become too weak to have much more effect. The dose is front loaded, and gets weaker as time goes on. This is usually given by itself or with hormone therapy, depending on the risk of the cancer, and depending a bit on the oncologist doing it.


The other type is temporary/HDR brachytherapy, where a single much more powerful seed is inserted for about 10 mins and then taken out, and the treatment is finished when you go home. However, a single HDR brachytherapy session doesn't work well as you need multiple radiotherapy sessions (or a long one as in the case of LDR) to be effective. Originally, 4, or 2 HDR sessions were done, but much more common in the UK today is that one HDR session is given, and the other is swapped for a half dose of external beam radiotherapy (known as HDR Boost). This is usually also given with hormone therapy (mainly for the benefit of the external beam radiotherapy).


The combination of HDR/external beam/hormones is good for high risk patients up to T3b. LDR brachy tends to be used for lower risk patients G3+4, T2N0M0, but can go up to T3a in some cases.


I had HDR Boost, and 2½ years later, I'm at the tail end of recovery and everything is working, except ejaculations are mostly dry (as expected). So far, I'm pleased with the result and in a much better state than I imagined at the outset. It will be another year or so before I know how successful the treatment was, but it's looking good so far. However, I'm aware I was a high risk patient, with perhaps a higher chance of recurrence.

User
Posted 11 Mar 2022 at 05:41

Hi Andy, thank you for your reply.  As my husband is PSA8, T2A, Gleesen 4+3 N0M0 I would assume reading your comments that he would be in for LDR.  Why HT with all the attendant nasty side effects?  And please do not say that hot flushes are not nasty, the same for lack of libido.

User
Posted 11 Mar 2022 at 07:05
HT is clinically proven to improve the outcomes.

User
Posted 11 Mar 2022 at 07:21
Not everyone gets hot flushes during HT; I didn't. I didn't find HT too unpleasant at all. Fatigue was the most noticeable side-effect for me.

The reason for HT is that it prevents the cancer cells from dividing while the radiation kills them. The radiation damages the DNA of all the cells in the vicinity; healthy cells can repair their DNA but in cancer cells this repair mechanism is usually faulty so the cell will eventually die, but this can take up to 18 months to happen. The HT holds the cancer in check while it gradually dies.

Best wishes,

Chris
User
Posted 11 Mar 2022 at 12:28

Hi,


I had PSA 2.19 and Gleason 3+4=7 and 5 cores out of 20 positive all contained within the prostate.I had the choice of Robotic surgery and Brachytherapy and after reading up about possible side affects i went down the Brachytherapy Low dose inplant route as i felt it was less invasive. I had the procedure in Mount Vernon London and was in for two days and apart from slight discomfort and regular trips to the bathroom all was well.I was given pain killers and used very few of them and laxatives that i never used ,Also had  Tamulosen that i took for six months and decided i did not need them anymore. ED was a problem and still is and i was prescribed  4 Viagra per month.


I had my Brachytherpy in September 2016 with PSA 2.19 and after six years with no incontinence or other real side affects i was signed off by my Specialist in January 2021 with PSA 0.05.


If you click on my Avatar you can follow my journey.


John.

 
Forum Jump  
©2024 Prostate Cancer UK