As with most things , I think the drugs have a bigger effect at the start and then your body adapts to them gradually. I had bad fatigue at the start and am now 18 months in. I still feel the fatigue and maybe it has got worse in some ways , but I’ve just learnt to live alongside it. I still work damn hard on a farm but just less hours. And I’ve learnt for the first time in my life at 55 yrs old that there is nothing wrong with a quick nap when you need it. Stay active and don’t give in to it if you can. And keep your joints moving as muscle pain can catch up on you. Not sure about the diarrohea but I’ve had IBS for a while anyway. Keep strong