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PIRADS score 4, PSA 5.8

User
Posted 16 Mar 2022 at 22:59

Had a health MOT a few weeks ago and doctor noted PSA was 5.8, so an MRI was arranged. I have no other prostate symptoms, no issues with urine flow etc.


Consultant called a few days later and said 2 lesions were found, with size of 5mm & 2mm, so I have a biopsy arranged for a couple of days time.


Today a letter arrived with some furthers details of the MRI scan, it said the location was in the transitional zone of the prostate anterior and the PIRADS score is 4.


Although the biopsy will give a definitive answer, I'm now keen to know what all this means.


I believe the biopsy will be done using MRI/TRUS fusion, under local anesthesia. Has anyone had a biopsy using this method and how uncomfortable was it?


If cancer was found, what would the options? Would they decide on watchful waiting or use surgery/radio therapy or other procedure.


I know these questions cant be answered now, but I'm just trying to see how this might play out.

Edited by member 20 Mar 2022 at 12:03  | Reason: Not specified

User
Posted 19 Mar 2022 at 20:34

Hi, yes always a worry but at least you're in the system now and it all will get sorted.


A good page on understanding pirads and MRI - perhaps toooo much info


https://radiologyassistant.nl/abdomen/prostate/prostate-cancer-pi-rads-v2


 


Plus a whole load on my blog , see profile....if you comment I'll get back in touch.


 


Cheers

Edited by moderator 13 Jul 2023 at 18:08  | Reason: Not specified

Steve


Blog: prostatecancer.vivatek.co.uk

User
Posted 26 Mar 2022 at 13:21

Had a letter today from the hospital with an appointment in 3 weeks to see the prostate clinical nurse specialist where the biopsy results will be shared.


Not sure if there is any significance in seeing a clinical nurse rather than a consultant, still will find out in due course.


 

User
Posted 15 Oct 2022 at 13:51

After a lot of research I decided to go for 4D Brachytherapy which I had done about 5 weeks ago, this technique is minimally invasive and seems to have the least side effects and best outcome for low to intermediate PC.


The procedure is done under general anesthesia and ultrasound guidance, I had around 70 tiny radio active seeds inserted very accurately whilst I was sedated. When I woke about an hour later I was a bit sore and had a catheter fitted.


They kept me in overnight and once the catheter was removed, I had to drink loads of water and have the output measured. When they were happy I was peeing enough they let me out in the morning. I was back at work a few days later.


So far so good, no major side effects although I have some irritation from the radiation and urgency to pee.


The radioactivity dies down after about 6 months and with any luck the cancer will be gone.


I'm due to see the consultant in a few weeks and have my PSA checked, then re-checked every 3 months for the first year, then annually.


I would definitely recommend 4D Brachytherapy to anyone else in the same situation as me.


There's a really good video about 4D Brachytherapy here: -


https://www.youtube.com/watch?v=JXaL3zlGTyU&t=318s

Edited by member 15 Oct 2022 at 15:38  | Reason: Added video

User
Posted 15 Oct 2022 at 15:35

Yes the biopsies did confirm cancer, of the 12 cores taken, 4 showed evidence of low to intermediate cancer with 10% pattern, the maximum core length with cancer was 4mm. There was no evidence of spread to lymph nodes or metastasis.


It was determined that I was Gleason 3+4=7, T stage 2, grade group 2 with a prostate size of 32cc.

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User
Posted 17 Mar 2022 at 08:35

Hello SunnyJim,
Commiserations on joining the p/c club - but it is a big one! I can't really try to answer your questions re options because they will depend on what the examinations find, but yes, they could range from waiting/observation to destroying the cancer by surgery or by hormone therapy / radiotherapy. Please note - 'they' will not decide - they will make recommendations based on what they find, and you will be asked to choose what you want to do. If you really want to investigate the options you could download the Prostate Cancer UK 'toolkit' which will explain everything very clearly. Most of all, though - don't fret and don't panic. Things might seem to move slowly, but you are at the start of a well worked-out procedure. Don't get into the 'but what if...' line of thinking. Trust the people who are looking after you. If you do opt for treatment, it will not be pleasant at times, but it will also not be horrible. You will get through it. I know, because I did.
best wishes,
Hermit

Edited by member 17 Mar 2022 at 09:07  | Reason: Not specified

User
Posted 17 Mar 2022 at 09:04
Thanks for the reassurance Hermit, I will download the tool kit and have a read, also the surgeons looking after me are top-notch, so I feel that I'm in good hands.
User
Posted 17 Mar 2022 at 17:38

Hi Sunnyjim, after reading all the treatment options I would say they sound pretty nasty.  The only acceptable part is getting rid of the cancer.   


 

User
Posted 17 Mar 2022 at 17:47

Hi sunnyjim, We have had members on here with worse looking figures than yours who have been found clear on biopsy.

Dave

User
Posted 18 Mar 2022 at 15:04

Hi sunnyjim, the biopsy is not pleasant by all accounts according to my OH, but needs must as it were. On the plus side, it’s soon over and is fairly quick. He felt a bit bruised afterwards but that went after 3-4 days and it didn’t stop him doing anything. Good luck. 

User
Posted 18 Mar 2022 at 15:33

Given they have identified 2 legions they should be able to target these and give you a definitive answer on whether its prostate cancer or not. If it is they will advise the Gleason score which will be an X + Y number. where X and Y are between 3 and 5 ( lower is better and the first number is the more predominant grade.) This plus the staging and location will help them determine suitable treatments. Good luck

User
Posted 19 Mar 2022 at 20:34

Hi, yes always a worry but at least you're in the system now and it all will get sorted.


A good page on understanding pirads and MRI - perhaps toooo much info


https://radiologyassistant.nl/abdomen/prostate/prostate-cancer-pi-rads-v2


 


Plus a whole load on my blog , see profile....if you comment I'll get back in touch.


 


Cheers

Edited by moderator 13 Jul 2023 at 18:08  | Reason: Not specified

Steve


Blog: prostatecancer.vivatek.co.uk

User
Posted 20 Mar 2022 at 12:30

Thanks for all the replies, I just noted the PIRADS score in the title was 5 whereas it should have been 4, so I have edited that to avoid any doubt.


I had the biopsy done last Friday lunchtime, the surgeon used fusion guided ultrasound, whereby the ultrasound probe was inserted into the rectum and the image merged with the images from the MRI scan taken the previous week.


This was all done under local anesthesia with the biopsies being taken through the transperineal  area. A nurse first applied a numbing gel and then I received 2 numbing injections, one of which was directly into the prostate.


A total of 16 biopsies were taken, 4 from the area of interest and 6 either side, my lesions are in the transitional zone anterior region. The staff were very good and kept me talking throughout to distract me.


I wouldn't say the procedure is painful but it's certainly uncomfortable and I'm still sore 2 days later.


I haven't had any blood in my urine but haven't tried ejeculating yet.


At the end of the procedure, I was shown the combined MRI and ultrasound, I could see exactly where the needles had taken samples.


I was a bit shocked to be able to see the lesion on screen, having been mapped out by the surgeon and fusion software.


Have been taking this weekend very easy and just relaxing, not feeling up to doing much and anxious as to what the biopsy samples will reveal.

Edited by member 20 Mar 2022 at 13:03  | Reason: Not specified

User
Posted 20 Mar 2022 at 12:39

Wow!  I'd have loved to see any scans.


It may sound odd but you were fortunate in having the TP biopsy. Most places are doing these now but not everywhere.


I had no choice. TRUS it is....peak Covid and no option. More dangerous as those harpoons go thru the rectal wall into the prostate...so shed loads of antibiotics before, during and after. I know several friends who caught sepsis! Small consolation, i know.


Yes, take it easy no lifting....try and chill in the sunshine. Small amounts of blood in the urine normal ..mine went from the urine in a day or two. Blood in semen a bit scary but not once you're expecting it, that cleared up quickly....


My neighbour had 24 cores taken via TRUS, ouch! But had NO cancer at all. Weird.


Have a look at me blog...I'll doubt you'll be exactly following me but there's shed loads of info on there....


Cheers


 

Edited by member 20 Mar 2022 at 12:40  | Reason: Update

Steve


Blog: prostatecancer.vivatek.co.uk

User
Posted 20 Mar 2022 at 23:48

Hi Esteban,


I read through your blog and can see you have gone through a lot, I can only sympathize and hope you are now cleared of disease.


The hormone therapy seems to have a negative effect emotionally and I fully expect that I would respond in a similar way, if they were prescribed. I love my red wine, so wouldn't be too pleased about cutting down.


I don't know how my diagnosis will play out and I'm now anxiously waiting for the biopsy results.

User
Posted 26 Mar 2022 at 13:21

Had a letter today from the hospital with an appointment in 3 weeks to see the prostate clinical nurse specialist where the biopsy results will be shared.


Not sure if there is any significance in seeing a clinical nurse rather than a consultant, still will find out in due course.


 

User
Posted 26 Mar 2022 at 13:27

Hi.


No, not really. Mine lasted exactly 13 minutes. I recorded it.


Take notes....ask questions....what does this mean....what choices do I have . .who can i contact  etc.


Be kind to yourself and enjoy the golden zones....those times in-between anything happening.


I've got a blood test (FBC and PSA) next week but I'm not worried - now .


No, right now I'm sitting on an secluded, hard to get to beach, naked and enjoying the sun!


Keep us posted buddy....


 

Steve


Blog: prostatecancer.vivatek.co.uk

User
Posted 26 Mar 2022 at 15:53
Thanks for the reply Esteban, tried to PM you but blocked as I'm a new member with insufficient posts?

Anyway, enjoy your day on the beach :)
User
Posted 26 Mar 2022 at 18:09

Ok I'll pm you 

Steve


Blog: prostatecancer.vivatek.co.uk

User
Posted 28 Mar 2022 at 14:04
Hello sunny Jim. My hubby (62) is going through the process now with a prostectomy due next Friday (although he’s just had Covid so they may have to cancel - which would be annoying!

He presented with PSA of 4.2 (quite low) but he had the MRI which showed a localised 14mm lesion. Gleason score of 3 +4. Pirads 4.

He was very unsure whether to have HIFU (high prequency zapping) or full prostectomy. He really didn’t relish the thought of the after effects of the op. However after a few weeks and lots of consultants advice he chose the op. I was quite glad as it feels a little more “final” than HIFU.

He had pre op blood test last week and his PSA has already risen to 5.8 so I think he’s very lucky to have got it checked out when he did! He had a couple of symptoms that made him go to the doc, mostly with nothing to do with the PC as it turns out!

Good luck on your journey. The diagnosis was definitely the most stressful part.

User
Posted 15 Oct 2022 at 13:13

What was the outcome Sunnyjim, my husband in a similar situation, waiting on biopsy results now?

User
Posted 15 Oct 2022 at 13:51

After a lot of research I decided to go for 4D Brachytherapy which I had done about 5 weeks ago, this technique is minimally invasive and seems to have the least side effects and best outcome for low to intermediate PC.


The procedure is done under general anesthesia and ultrasound guidance, I had around 70 tiny radio active seeds inserted very accurately whilst I was sedated. When I woke about an hour later I was a bit sore and had a catheter fitted.


They kept me in overnight and once the catheter was removed, I had to drink loads of water and have the output measured. When they were happy I was peeing enough they let me out in the morning. I was back at work a few days later.


So far so good, no major side effects although I have some irritation from the radiation and urgency to pee.


The radioactivity dies down after about 6 months and with any luck the cancer will be gone.


I'm due to see the consultant in a few weeks and have my PSA checked, then re-checked every 3 months for the first year, then annually.


I would definitely recommend 4D Brachytherapy to anyone else in the same situation as me.


There's a really good video about 4D Brachytherapy here: -


https://www.youtube.com/watch?v=JXaL3zlGTyU&t=318s

Edited by member 15 Oct 2022 at 15:38  | Reason: Added video

User
Posted 15 Oct 2022 at 14:16

Thanks for your reply, hopefully you're well on the way to recovery now. So I presume from your reply cancer was confirmed. My husband had a PSA of 4.7, then 3.2 a month later, and dre showed enlarged prostate. BPH was presumed but then MRI showed 2 "growths" which were given a "low 4 on pi-rads scale". I know there's a high chance it's cancer but guess we won't know for sure until biopsy results come back, the waiting game is the worse part, I think.

User
Posted 15 Oct 2022 at 15:35

Yes the biopsies did confirm cancer, of the 12 cores taken, 4 showed evidence of low to intermediate cancer with 10% pattern, the maximum core length with cancer was 4mm. There was no evidence of spread to lymph nodes or metastasis.


It was determined that I was Gleason 3+4=7, T stage 2, grade group 2 with a prostate size of 32cc.

 
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