Thanks for your reply, Dave. His last blood test was two months ago and at that time his PSA was well below 1 - as it has been since he started the enzalutimide last October. He will be having another blood test before we see the oncologist next week, so, fingers crossed his PSA is still very low. His hands have been swollen ever since he's been on hormone therapy and the specialist nurse told him a couple of years ago that it was likely to be a side effect of the medication. He was only on decapeptyl injections at that point and he is still having those, as well as taking the enzalutimide. So, I'm hoping that side effects are the reason for the further swelling.