Was doing research on my husband's (age 77) mood swings, anger, irritability and prostate cancer surgery. He has been cancer free (PSA after operation 0) for over 13 years. He said his doctor had told him that an area that was cut into in the operation would change his personality. And then it's happened. From a happy, smiling man who never was upset, he's become increasingly moody, angry, pounding fists at times, bad tempered, whiny which has been quite a shock. This transformation took place right after the operation and has steadily progressed as time has passed. He still gets a PSA test yearly and not it's bi-yearly even though his numbers are excellent but he continues to worry each and every time. I saw a post on this site from 2017 where someone was asking the same questions about a friend of theirs whose personality changed drastically after 5 years. I should also mention my brother-in-law had prostate cancer and has been free of it for over 15 years as have his neighbours, so there is excellent recovery from this. I should also mention that i read the book by the 'founder' of PSA who says it's being used in the wrong way, and he - himself never gets his PSA taken nor does he advise anyone he knows to have it taken either. So that, in itself is puzzling. Looking for others who've noticed personality changes in their spouses.