Stew, no experience of chemo ,but local radiation treatment to a single pelvic lymph node tumor has caused my PSA to rise from 1.8 to 4.6 in six months. My PSA is rising fast now than when I had a cancerous prostate.
When I asked the oncologist for an explanation he said he couldn't give one ,"it sometimes happens."
Hope you find an answer to your question.
Thanks Chris