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Treatment Required for PSA of 30?

User
Posted 10 May 2023 at 06:49

Hi All.  New to this forum, so hope this is the right place for the post! 

My Dad has been diagnosed with Prostate Cancer for several years now (He is 82 with several other health issues).  Luckily it is slow growing slowly, and he has been told to just monitor for the last 5 years or so, and it may need some radiation treatment at some point to shrink it.

He gets his PSA tested every 6 months or so (initially it was around 15), over the last couple of years it has started to creep up. 

Previously we were told, to 'just monitor' until it his PSA hits 17 then they will re-assess.

Then when it hit 17 we were told to monitor it until PSA 20, then again when it hit 20 to monitor until it hit 25, same thing happened again to PSA30.

He has recently hit PSA30, and again we have been told to just monitor, and now we 'don't need to worry' until it hits PSA40.

With his other health conditions and age, Operations are out of question. 

However,  I am concerned that we keep getting a change of story and told to just wait until the next threshold is hit, and one day it will be too late to do anything. 

From my understanding a PSA of 30 is already really high.

Is it normal for a PSA30+ to be left with no intervention ? or at least discussion of what that prognosis means.

Thanks.

User
Posted 10 May 2023 at 08:58
Are you sure that you have all the information? Is it possible that the doctors are discussing options and your dad is choosing (or at least agreeing) not to have treatment? Does he have hormone tablets or injections?

Is he under a urologist or is it an oncologist?

At 82, it may be that your dad is reluctant to have treatment that can have unpleasant side effects or that the oncologist feels he isn't fit enough for.

When did he last have an MRI scan?

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 10 May 2023 at 09:29

It would help if you could get your Dad to ascertain and make available his histology. To have been diagnosed with PCa he must have at least have had a biopsy and most probably an MRI scan. His Gleason score would have been given and also his staging. It rather looks that due to Dad's age and other problems, it was thought that the advancing cancer was slow and it would not be in Dad's interest to have treatment for a relatively short time. Nevertheless, I feel the situation should have been explained and discussed with him and if he feels strongly enough to have a reassessed appraisal based on at least a new MRI and quite possibly a new biopsy. We don't know your Dad's attitude to this. He may have said he is content to do nothing by way having treatment as this may well adversely impact his remaining years. I feel it could be beneficial if Dad could have a meeting with his consultant and be accompanied by you or another member of his family or close friend to clarify the situation.

Edited by member 10 May 2023 at 09:31  | Reason: Not specified

Barry
User
Posted 10 May 2023 at 10:21

Thanks for the quick response all.

Yes he has had MRI/Biopsy several years ago to confirm the diagnosis (Gleason 3+4 back then) and he did have a radio pellet inserted to shrink it (about 4-5 years ago).

Hes been trying to contact the Urologist as he has had a pain in his groin (which they told him to contact them if it happens), but has been unable to get through.
Hes reverted to seeing his GP for this (who say they dont think it is prostate related luckily), but they are sending him for an x-Ray to review

I understand at his age there may not be a lot of actual treatment options, and dad may know a bit more than hes letting on.

Saying that though, he was pretty stressed when they told him to wait until PCA40 ... his words were along the lines of... they told me that when it hit 20 they would intervene and said same thing again when it hit 30 (Radiation for 5 days for 5-7 weeks), now they are saying to just wait again until its 40..  

So I dont think he had a discussion about an actual prognosis and 'No treatment' options. 

We are pretty resigned to the prognosis likely being there isnt much that can be done, but would be better for that to be clear. 

I know each case is different, but would it be normal for some sort of intervention to have happened by the time of PCA30? 

Unfortunately, arranging to actually speak to the consultant is the hard part in current climate 

User
Posted 10 May 2023 at 12:14
It should be a decision from your dad based on informed consent to the approach and treatment regime.

It may be a good idea to go along with him to his consultation assuming he will let you.

The questions you raise should be addressed to his consultant.

User
Posted 10 May 2023 at 13:19

Hi again,

Firstly, if Dad cannot get through to his Consultant directly, he could ask the Hospital to put him through to his/her Secretary with a view to getting an appointment. It doesn't sound like he has been allocated a specialist nurse because if he had, s/he should be able to assist if contacted.

It may well be that due to age and other problems, a Prostatectomy would be ruled out but most men are able to have RT and tolerate it well. It is usually given in conjunction with HT (Hormone Therapy). In advanced cases, which Dad's may well not be, HT and chemo might be options. HT does seem to produce more side effects in men than RT. The staging represents how advanced the PCa is and this usually determines, along with other individual contraindications, what treatment might be ruled out. We don't know this in Dad's case and it may be a factor in determining the way forward here.

You are right that most men with a PSA of 30 and a Gleason of 3+4 would expect to have some form of treatment other than when there are reasons why an individual is unsuitable or doesn't wish to have it.



 

Edited by member 10 May 2023 at 13:22  | Reason: Not specified

Barry
User
Posted 10 May 2023 at 15:59
I can see that if it has taken 5 years for PSA to double from 15 to 30, they are going to conclude it is a very slow growing tumour that doesn't need any urgency for treatment as long as it isn't causing problems. Is your father fine with things like urine flow rate? Urination problems are the sort of symptom that can emerge with a growing tumour and do need dealing with.

But (assuming your father has shared everything with you) it does sound as if the consultant is not being very open about why treatment is not currently being considered. I like the suggestion above about asking to accompany your father next time he has an appointment so you can share the understanding of what is being decided.

User
Posted 10 May 2023 at 18:48

Originally Posted by: Online Community Member
Yes he has had MRI/Biopsy several years ago to confirm the diagnosis (Gleason 3 4 back then) and he did have a radio pellet inserted to shrink it (about 4-5 years ago).

 

Okay, there is some misunderstanding or lack of clarity here I think. A radio pellet to shrink the prostate doesn't exist - it seems your dad had brachytherapy which is a form of radiotherapy used to treat prostate cancer by inserting radioactive seeds into the prostate. Once a man has had brachytherapy, he can't have any more radiotherapy of any kind in or around his pelvis, and cannot have the prostate removed surgically. This means there is no other curative treatment they can offer your dad and the only thing he can do is to have hormone tablets or hormone injections to slow the growth of the cancer down. 

It might be that he is already taking hormone tablets or having an injection every 3 or 6 months without realising that this is for his prostate cancer - do you know whether that is possible? If that's the case, the doctors may be delaying doing anything else because they don't think he is fit enough to have chemotherapy. Chemo doesn't kill prostate cancer, all it can do is slow it down and obviously, it can have some pretty awful side effects for an old man. 

If he is definitely not already having hormone treatment, then yes, this is what would normally be offered. But hormone treatment doesn't last forever and can have quite a serious impact on quality of life so perhaps the doctors just want to delay that for as long as possible. Or dad has some other medical condition that would make hormone treatment problematic. 

What are his other medical problems that you mentioned?  

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 10 May 2023 at 20:05

My Dad is 92 now, and his PSA has gradually crept up to the mid 20s over the last few years, but he takes Finasteride, which roughly halves measured PSA, so his PSA is probably around 50. He's not on any treatment, and refuses to discuss the matter with me (he's a grumpy old bugger!). I think that once you get to a certain age, it's often deemed best to simply let nature take whatever course it will.

User
Posted 11 May 2023 at 00:38

Originally Posted by: Online Community Member
 and it may need some radiation treatment at some point to shrink it.

I was also puzzled by the reference to a pellet to shrink the Prostate as this is usually tackled with HT.  Then there is the above reference to possible need for radiation treatment at some point.  Another possible explanation is that the pellet may be Zoladex or similar and may be regularly administered, in which case RT might then be a possibility. Then it could be that Dad was given a tablet to reduce an enlarged Prostate (BPH).

As we have said, it should be established what Dad's full diagnosis was, what treatment was given at the time and is ongoing (if any), apart from monitoring and when PSA tests were done and with what result, also any other scans and detailed biopsies, in other words Dad's full histology.  Dad is said to be concerned about his situation, another reason why he needs to know the thinking of his consultant based on his histology and have an up to date assessment and quite likely establish what is Dad's wish to accept what new is offered now or at some trigger point. 

 

Barry
User
Posted 11 May 2023 at 01:37

Thanks all for the advice.  yes it sounds like i definitely need to join a call with the consultant, and get current status.  

I really appreciate the feedback.

User
Posted 11 May 2023 at 09:42

Originally Posted by: Online Community Member

Thanks all for the advice.  yes it sounds like i definitely need to join a call with the consultant, and get current status.  

I really appreciate the feedback.

It is sounding like your father is resistant to treatment to me - at his age I cannot blame him. My own father had a similar outlook when he was 63 - he had very little treatment & passed away from PC aged 71.
Ok it was the 1980s & not so many treatment options, then. With a PSA of 30, I very much doubt he is having any treatment at all - so HT might be an option. Though it can make you weak - if he is already frail, that might make him liable to falls etc.

 
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