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Please help me underestand...

User
Posted 24 May 2023 at 14:46

Just hope someone can help me get my head around this...

My dad's PSA at diagnosis was nearly 1700, that was over 7 months ago. He's on hormone therapy (drugs and injections) and now his last measured PSA was 2.54. We have been told that this is a good result, but the doctor wants to him to do chemo if it doesn't reach 0 soon.

He has mets in the spine and ribs.

My question is - is the cancer still progressing with the PSA at 2.54, albeit at a slower rate?

Wd

User
Posted 24 May 2023 at 20:22

I think this is probably how it works...

The numbers suggest the hormone therapy has knocked it back by 99.85%, which is a massive reduction.

However, there's still 0.15% of the prostate cells active, which might be cancer potentially growing, and the oncologist wants to try and hit that with chemo to stop those cells growing. This is with the view of making the hormone therapy work for longer.

Best thing is to ask the oncologist if this is the situation.

User
Posted 24 May 2023 at 23:36
Thanks - this is helpful.

My dad is not taking any of this very well so we are very distressed by it all.

best wishes to you!

Wd

User
Posted 25 May 2023 at 01:07

Gosh, don't be distressed about it - I think the onco is causing you unnecessary worry! Your dad's PSA is great and shows that he has responded to the HT really well. The cancer will not still be growing because it is being starved.

Not everyone gets down to 0.something on HT - this does not mean that the hormones aren't working. Onco sounds like a bundle of laughs - I suspect that if you were able to speak to the specialist nurse or a different oncologist, they would reassure you that the PSA is fine.

 

I think that the onco is being a bit of a bully. I wonder if he would be quite this way if you went along with dad to the next appointment and just clearly state that your dad does not want chemo. In the country where your dad is, do doctors get paid a lot of money to do chemo? 

Edited by member 25 May 2023 at 01:09  | Reason: Not specified

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 25 May 2023 at 07:02

It is best practice to hit metastatic PC hard with chemo and / or second line HT plenty of clinical evidence (and guys on here) that proves it is an effective treatment strategy.

Of course this must be balanced with the ability or desire of the patient to tolerate the side effects and impact on QOL.

Ultimately it is your dad's choice.

Edited by member 25 May 2023 at 07:03  | Reason: Not specified

User
Posted 01 Jun 2023 at 23:59

Hi Francij - I think if my dad were much younger, he might have opted for the chemo. But he was extremely debilitated last year after his blocked prostate caused his kidney function to plummet to  a level nearly requiring dialysis... and so although his urologist strongly urged chemo, the oncologist declined as he thought my dad was much too weak. Fast forward to now, 7 months later, and he hasn't seen the onco since. The urologist, however, is still pressuring him about the chemo. I understand the aggressive treatment style is designed to make treatment more effective, but I'm wondering if he can tolerate the chemo at this stage? His kidney function still isn't great, he is terribly depressed, doesn't exercise and often doesn't eat well. He used to be in good shape for a man his age just before all this happened. So I think he's going to refuse it... but be tormented by his choice at the same time.

WW

 

User
Posted 02 Jun 2023 at 00:08

Hi Lyn - money is always a possible motivation in this private healthcare system, alas... the stories I could tell! His urologist is supposed to be very competent but has an astonishingly poor bedside manner; brash, arrogant, I could go on....needs to be "handled" carefully for best results.

I am just hoping the cancer hasn't progressed further with the PSA brought low, but not quite to 0. My dad has not complained about any bone aches or pains, his main complaints are from the side effects of the HT which include excessive itching, and he is _still_ incontinent after 7-8 months... I've only just downloaded him the NHS Squeezy app - he hadn't been given any advice or support on that front either.

We see the doc again in a week's time. Fingers crossed....and thank you again for the support. We've not been able to talk to anyone in the same boat here, with advanced PCa, so having an online community helps.

WW

 

 
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