I was on Zoladex for 3 yrs (together with 2yrs abiraterone, enzalutimide, prednisolone on trial). Very soon after treatment started blood pressure increased (had to temporarily stop abiraterone, enzalutimide) checked out, started BP tablets and obv still on them now, nearly 8 yrs later. ( guess may have needed BP tablets at some time as my twin brother had been on them for few yrs& 2 sisters were).
Cholesterol increased but gp not too bothered&accepted HT probably contributed, same with the diabetes angle as that became pre diabetic.
Last summer, after routine bloods at GP, started statins tho GP said stats had gone down as a few years after effects of HT but along with age etc good practice to have statins.
Diabetes angle had settled down well enough.
Suppose I was fortunate in that GP accepted that HT has several effects and happy to wait to act, obv there was no 'danger'.
Bloods were still showing a couple of anomalies but slight although Zinc was low and advised to take multivitamins that had Zinc in them, levels will be checked again in a month or so.
So, it seems certain that HT does affect the likes of cholesterol, BP, diabetes plus others but in general things improve once HT wears off.
Peter