I am 22 months into a 36-month Zoladex course for my locally advanced PC. After about 12 months I developed stiffness in my feet, legs, and especially in my hands. The stiffness has been with me ever since. More recently the stiffness in my hands has increased and become painful. Steroid injections have helped a bit with the stiffness.
I had 6 x chemo followed by 37 fractions of radiotherapy but the ongoing HT has been the most difficult. Side effects wise I seemed to have copped the lot - hot flushes, weight gain, fatigue, and joint pain. I believe that these side effects will decrease after the Zoladex is stopped but I understand this can take some time.