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Interesting twist to intermittent HT

User
Posted 08 Mar 2024 at 23:50

This video is interesting in that it discusses Intermittent HT, the scenarios in which it is beneficial and possibilities of using PSMA PET and Intermittent HT to get a durable remission.

https://youtu.be/k92ETEqVYJ4?si=hVCT1pfETnhytJP4

 

User
Posted 08 Mar 2024 at 23:50

This video is interesting in that it discusses Intermittent HT, the scenarios in which it is beneficial and possibilities of using PSMA PET and Intermittent HT to get a durable remission.

https://youtu.be/k92ETEqVYJ4?si=hVCT1pfETnhytJP4

 

User
Posted 27 May 2024 at 21:30

Ask the nurse to ask him.

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User
Posted 20 May 2024 at 09:51

Great news. I'll be asking my medical oncologist about a holiday soon. I've been on ADT for 7.5 months. Last two PSA tests were <0.1. Diagnosed as Gleason 7(4+3) with met to L1. Went with radiation, Lupron, and Zytiga

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Edited by member 21 May 2024 at 09:40  | Reason: Not specified

User
Posted 27 May 2024 at 12:40

Thanks francij1 that's one chat for my next appointment, even if nothing comes out of it, my understanding of the little 'B' will be improved

Edited by member 27 May 2024 at 12:42  | Reason: added

User
Posted 27 May 2024 at 14:20

Intermittent hormone therapy has probably been used much more in the UK than the US, although it's also probably not used as much here as it could be. Some research here showed it made almost no difference to the length of time it takes to become castrate resistant. Obviously, it's only suitable where the HT brings PSA down to undetectable, and where PSA is relatively slow to rise during the holiday period. For those men, they typically spend more time off HT than on it.

A complication now might be that some of these men will be on an additional novel hormone therapy medication too (Abiraterone, Enzalutamide, etc), and under the UK drug funding rules, you can't restart those after you've stopped them.

Intermittent hormone therapy is not used when you are on time-limited hormone therapy as part of radiotherapy treatment with curative intent. It's normally only used for patients who have relapsed and/or have a low metastatic tumour burden. In the UK, we have had the option to treat very small numbers of mets with SABR radiotherapy in circumstances that used to be considered incurable, although not enough centres actually offer this.

The idea of using the HT holidays to scan for mets is a good one. The rationing of PSMA PET scans in the UK may be a limiting factor, particularly at treatment centres which don't have their own PSMA PET scanners.

User
Posted 27 May 2024 at 19:39

I was excited to watch this at first as DH is hating the drugs. He was so fit and healthy before starting on them. PSA went from 4.7 down to just over 1 after being on bicalutamide for 4 weeks and zoladex for 2 weeks. Then more or less undetectable 4 weeks later. Enzalutamide was added a month or so later. So would probably work for him. Then I read Andy’s post about not being able to restart enza. So that’s that then. 

Edited by member 27 May 2024 at 20:06  | Reason: Not specified

User
Posted 27 May 2024 at 19:58

Originally Posted by: Online Community Member

This video is interesting in that it discusses Intermittent HT, the scenarios in which it is beneficial and possibilities of using PSMA PET and Intermittent HT to get a durable remission.

https://youtu.be/k92ETEqVYJ4?si=hVCT1pfETnhytJP4

 

 

Why doesnt this new finding  not surprise me ?

User
Posted 27 May 2024 at 21:10

Originally Posted by: Online Community Member
Enzalutamide was added a month or so later. So would probably work for him. Then I read Andy’s post about not being able to restart enza. So that’s that then.

Talk with his oncologist and see what he says. There may be some protocol for this I'm not aware of.

User
Posted 27 May 2024 at 21:17

Thanks Andy. We don’t actually get to speak to the oncologist. We haven’t even met him. DH just gets a phone call from the nurse every 12 weeks. But it’s something to ask if we ever get to see him. 

User
Posted 27 May 2024 at 21:30

Ask the nurse to ask him.

User
Posted 16 Jul 2024 at 12:13

Hi Francji1 asked about hormone holidays and not for me as I'm on 24 week Decapeptyl injection so would not apply and also to far down the line, Thanks again was worth the question, also I was asked if I would like to sit by and watch my PSA rise hoping that the hormone treatment would take me back to the same low PSA when resumed?

 
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