Oestrogen

I think you mean Dr 'snuffy' Myles. 'Sniffy' Myles was a gynaecologist.

😉 x.

Hi Adrian 

Yes I meant Snuffy but I am correct with Myers😊

I was heading for his Wikipedia page but this came up 

https://www.amazon.co.uk/Beating-Prostate-Cancer-Hormonal-Therapy/dp/0967612926

I know who you meant. 👍 I just couldn't resist the funny typo. I'm rubbish at typing especially on a mobile. I have to edit nearly all of my posts because of typos.

That was put there at the beginning of COVID when they couldn't recruit anymore, but they already had enough recruits to provide sufficient data, so the data collection and analysis has continued.

The trial showed better (fewer) symptoms than the LHRH hormone therapy medications.

Their definition of castrate level was quite high at 1.7nmol/L, although I don't know what levels they actually achieved. There is no official or universally accepted castrate level, and values between 0.7nmol/L and 1.7nmol/L are used by different researchers/projects. The LHRH hormone therapy medications aim for no more than 1.2nmol/L, and often achieve 0.7nmol/L or lower (mine varied between 0.2nmol/L and 0.4nmol/L). Other trials have shown these low levels are more effective, certainly for metastatic patients.

Up to now, the PATCH trial has reported on the ability to control Testosterone levels, and the side effects, but not on the control of the cancer itself - it takes longer before you can report on that outcome. The Phase III extension of the PATCH trial will report on how the Estradiol patches actually controlled the cancer compared to the LHRH medications, i.e. recurrence for locally advanced patients, and overall survival for metastatic patients. Given the high level they've defined for castrate level, those results could be different than for the LHRH hormone therapies, particularly for patients not also on a novel hormone therapy tablet too (Abiraterone, Enzalutamide, Daralutamide, Apalutamide). It will be very interesting to see the results.

Hi 

It may well be from a few years ago but it is still  the latest news / update and they promised that come Spring 2024 they will have results for us ?

This treatment could save men  like Deco from arthritis it can stop men dying of heart attacks and strokes men can still have a sex life and be without brain fog ?

Hi,

Just a wee update…my GP and my Physiotherapist both reckon I don’t have arthritis and I am waiting on the result of an X-ray I had on Thursday. They both manipulated my legs in various ways and when I didn’t scream with the ‘arthritis move’😊 My GP has diagnosed me with Hip Bursitis and the feeling is this has been brought on by muscle loss around the glutes. I have been doing specific exercise to strengthen my glutes and can feel a difference already.
This HT therapy though seems to work in cycles….as you know a few months ago I could hardly get off a chair and getting up from the floor was a nightmare. This was getting steady better before I started the glutes exercises and now, it’s no bother, what’s THAT all about?

Unfortunately, Estradiol didn't help men with having a sex life, because that's down to loss of Testosterone.
Yes, brain fog can be caused by lack of Estrogens, but it's also caused by anti-androgen drugs (such as being on Bicalutamide alone) which raise Testosterone and Estrogen levels, so that one's not a simple relationship with Estrogens alone.

Cancer outcome results for locally advanced patients are due sometime around now.
Cancer outcome results for metastatic patients are expected next year.

If the results are favourable, it will still required NICE to evaluate the costings, and I have previously mentioned some possible challenges in this area even though the Estradiol drug itself is cheaper - it's likely patients on patches will need much more monitoring and adjustment of dosing.

I think a more viable way to tackle this is with using the standard LHRH hormone therapy medications, but adding a low dose Estradiol patch to make up for the missing Estrogens. That way, the Estradiol dosing is not critical to your life saving/preserving/extending treatment, but just to improving the side effect profile, and then the monitoring of it isn't critical any more. Also you can take Tamoxifen to prevent breast gland growth, which you can't if you're on Estradiol patches as your hormone therapy.