I'm interested in conversations about and I want to talk about
Know exactly what you want?
Show search

Notification

Error

Take a look at this

Email this conversation Print this conversation
User
Posted 29 Apr 2024 at 20:19
User
Posted 30 Apr 2024 at 07:51

In the particular video that Roger links to the men involved have advanced cancer with psa above 50 and even beyond 1,000.

Given that the cancer is "advanced" [and not merely locally advanced],  treatment is inevitably going to be some form of HT, RT [and maybe chemo].

I don't think there's going to be too much debate at the advanced level with the only slight proviso being that with advanced prostate cancer and mets in various parts of the body it's possible that removing the prostate might stop messages being sent to micro-mets to develop, but the first treatment for prostate cancer that has advanced outside the prostate is not likely to be RP

Jules

Edited by member 30 Apr 2024 at 08:21  | Reason: Not specified

User
Posted 30 Apr 2024 at 09:29

There is an established protocol in the UK now of offering men with metastatic disease but low metastatic tumour burden (not many mets) radiotherapy up front to zap the mothership. I think it was STAMPEDE which showed this slowed down the progression of the cancer.

However, a later trial revealed that the nuclear bone scans are liable to false positives when they show only a very small number of bone mets, so it was likely some of the men of the men thought to have low metastatic tumour burden who received radiotherapy had not actually been metastatic in the first place, and had a false positive from the nuclear bone scan.

Show Most Thanked Posts
User
Posted 30 Apr 2024 at 06:36

Dr Scholz's vids are certainly well presented and informative, however he does have quite a downer on RP already viewing it as a niche treatment, he may be ahead of the curve or being incorrectly presumptive, time will tell...

also he tends to assume unlimited resources and hence on demand access to PSMA scans, second gen HT, focal therapies the very latest chemo, SABR etc, this may not match your NHS or even UK insurance funded private health care experience.

Edited by member 30 Apr 2024 at 06:54  | Reason: Not specified

User
Posted 30 Apr 2024 at 07:51

In the particular video that Roger links to the men involved have advanced cancer with psa above 50 and even beyond 1,000.

Given that the cancer is "advanced" [and not merely locally advanced],  treatment is inevitably going to be some form of HT, RT [and maybe chemo].

I don't think there's going to be too much debate at the advanced level with the only slight proviso being that with advanced prostate cancer and mets in various parts of the body it's possible that removing the prostate might stop messages being sent to micro-mets to develop, but the first treatment for prostate cancer that has advanced outside the prostate is not likely to be RP

Jules

Edited by member 30 Apr 2024 at 08:21  | Reason: Not specified

User
Posted 30 Apr 2024 at 09:29

There is an established protocol in the UK now of offering men with metastatic disease but low metastatic tumour burden (not many mets) radiotherapy up front to zap the mothership. I think it was STAMPEDE which showed this slowed down the progression of the cancer.

However, a later trial revealed that the nuclear bone scans are liable to false positives when they show only a very small number of bone mets, so it was likely some of the men of the men thought to have low metastatic tumour burden who received radiotherapy had not actually been metastatic in the first place, and had a false positive from the nuclear bone scan.

 
Forum Jump  
Email this conversation Print this conversation

Join the online community now.

Click through to become a member and gain access to support, information and real time replies.




MenuTop ▲
©2025 Prostate Cancer UK