Hi I'm new to this forum but looking for some advice. My husband had prostate cancer in 2016, he had a lot of radiotherapy and zoladex for 2 years. In 2020 he was having excruciating back pain which was misdiagnosed 7 times at our A&E, they then gave him an MRI and discovered he had metastatic cancer on his spine, rushed to Queens hospital London where he had major surgery, then chemo, then Cyberknife radiotherapy and they put him back on Zoladex. Last year he got Lymes disease from a tic bite and was really poorly (not sure its connected) then his PSA kept rising, went to 19 and after another CT/PET scan discovered another growth on a different vertebrae. He was given more Cyberknife radiotherapy and put on Enzalutamide 4x daily. He hasnt felt well since and has terrible restless legs mainly when he sits down or lays down... he's going to the toilet several times a night and has terrible pains in his hip and knee which keep him awake. His Oncologist has lowered the pills to 3 a day but he's still unwell. He is tempted to stop the medication! Has anyone come off them? Has anyone suffered this much whilst on them? We are not even sure that its all down to the pills but something is not right. His PSA last month was at 2.4 so still higher than we would like but he only had the treatment in early December. Sorry for the podcast but trying to give as much detail as possible. Many thanks