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Should I have PSA and MRI?

User
Posted 10 Jun 2024 at 10:28

Whether to have a new PSA and an MRI scan after 24 years with elevated PSA (12-16)

I am 78-year-old, taking finasteride for an enlarged prostate. I have just had an appointment with a consultant urologist, following concerns about nocturia (x 3-4 times a night). DRE showed a ‘craggy prostate’ (this is not new: an earlier DRE 6 years ago also showed a slightly nodular prostate on the left). Ultrasound scan shows a 117-cc prostate. The consultant recommended a new PSA test and an MRI scan.

Background

I first started this ‘journey’ in July 2000 when I consulted a urologist about discoloured semen. However he was more concerned that I had a PSA of 13.4. and recommended a biopsy. The biopsy in September 2001 was clear. In March 2003 PSA was 12.4 and another biopsy was recommended. That was also clear except for a tiny area of PIN in one sample. November 2003. PSA 12.9

March 2005 PSA 16.2. Yet another biopsy was suggested, this time under general anaesthetic. This is where I decided to call a halt and to have no further PSA tests or biopsies and have maintained that position for the last 19+ years.

My problem following the recent consultant recommendation now is that I now have to decide what action to take:

  1. Do I continue my policy of non-engagement with PSA or would it now be wise to have a PSA test and MRI scan? Having had an elevated PSA (12-16) and survived the last 24 years with no obvious symptoms apart from urinary problems, do I continue in the same way?. This is of course a gamble, but it is one that I have taken for the last 24 years and I am still here (for the moment at least!).
  2. Do I take the consultants advice. My concern with this is that if I have a PSA and MRI I would again be on the merry-go-round of tests with the attendant stresses that I deliberately decided against 19 years ago. An MRI would probably show some cancer (at age of 78 most men probably have some cancer?). Even if low grade this could lead to possible over-treatment. I really want to avoid active surveillance with its continuous and stressful round of continuing PSA tests, MRI scans and biopsies. This would mean a life dominated by continuous anxiety, and rather than this I would perhaps rather continue the gamble that I have taken, but I remain rather undecided.

Has any else faced a similar dilemma? If so I would appreciate your experience and advice.

 

 

 

 

User
Posted 10 Jun 2024 at 17:49
Most men in your situation would have wanted to have got any cancer looked for/found and treated years ago. Had some of these men adopted your attitude they could be in a similar place to you before it is recognised so that shows there is there is overteatment. But then cancer does develop in some men to the extent in some that if it is not dealt with in a timely way, It will require greater and probably systemic treament in due course. So it comes back to deciding when and how extensively it's going to be looked for and acted on. Advances have been made but no certain way of predicting outcomes so it probably comes down to whether a man is comfortable to just carry on as the OP. If he is elderly and has other health problems he might well decide he doesen't want to look for cancer that might further degrade his life while another, perhaps younger man would want any cancer found and treated earliest so he would be less inclined to need treatment later and possibly extend his life. Don't forget the NHS don't want to treat a man who doesn't have cancer or one that looks insignificant. But cancer is often unpredictable. Sometimes it can go to sleep for ages and then become a problem.
Barry
User
Posted 11 Jun 2024 at 10:06

Hello Adrian56

Many thanks for you helpful and understanding reply.

As you say, it's a gamble that only I can take and I am still uncertain which way to turn!.

I appreciate you taking the time to respond.

Best wishes 

Richy

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User
Posted 10 Jun 2024 at 16:26

Hi Richy.

Welcome to the forum, which you could have perhaps joined 20 years ago. I truly respect and admire your decision, so far, to avoid other tests, scans and biopsies.

You certainly have a whopping prostate and presumably that explains your elevated PSA.

As you say, at your age, most men will have some degree of prostate cancer. I often think about  the thousands of blokes who are found to have prostate cancer when they die of something else. They all had obviously gone through life without diagnosis and the need for treatment.

Of course it would be wrong of me to advise you what to do, that's only a decision that you can make.

However, the stance you've taken thus far, may have  prevented you taking unnecessary radical treatment and years of side effects. Who knows?

Even though I'm a bit of a gambler, you're a man I'd never play poker with. 😉 

Your intuition doesn't appear to have let you down for the past couple of decades. If you were playing pontoon, and you had 16, would you stick or twist?

Whatever decision you make, I wish you the best of luck mate.

 

Edited by member 10 Jun 2024 at 16:39  | Reason: Additional text

User
Posted 10 Jun 2024 at 17:49
Most men in your situation would have wanted to have got any cancer looked for/found and treated years ago. Had some of these men adopted your attitude they could be in a similar place to you before it is recognised so that shows there is there is overteatment. But then cancer does develop in some men to the extent in some that if it is not dealt with in a timely way, It will require greater and probably systemic treament in due course. So it comes back to deciding when and how extensively it's going to be looked for and acted on. Advances have been made but no certain way of predicting outcomes so it probably comes down to whether a man is comfortable to just carry on as the OP. If he is elderly and has other health problems he might well decide he doesen't want to look for cancer that might further degrade his life while another, perhaps younger man would want any cancer found and treated earliest so he would be less inclined to need treatment later and possibly extend his life. Don't forget the NHS don't want to treat a man who doesn't have cancer or one that looks insignificant. But cancer is often unpredictable. Sometimes it can go to sleep for ages and then become a problem.
Barry
User
Posted 10 Jun 2024 at 21:58

My father was diagnosed at 76 and decided that all he wanted from the shopping list of tests, scans, treatments etc was the 6 monthly hormone therapy injections.
He didn't find the hot flushes too debilitating and carried on with his normal life until he passed at 84 with coronary heart disease.

I found out at age 62 so have been on the full journey of diagnosis and treatment so everyone is different in their approach.

Good luck with whatever you decide!

User
Posted 11 Jun 2024 at 10:06

Hello Adrian56

Many thanks for you helpful and understanding reply.

As you say, it's a gamble that only I can take and I am still uncertain which way to turn!.

I appreciate you taking the time to respond.

Best wishes 

Richy

User
Posted 11 Jun 2024 at 10:12

Hello Old Barry

Many thanks for your helpful and understanding reply.

There is unfortunately no simple answer and it all comes down to a personal choice of course - but it is a hard choice to make for me. 

Thanks again and best wishes.

Richy

 

User
Posted 11 Jun 2024 at 10:17

Hello Steve86

Many thanks for your response

I was very interested to hear about your father's experience with hormone injections and will look into it more.

I appreciate you sharing your thoughts.

Best wishes

Richy

 

User
Posted 12 Jun 2024 at 07:07

Richy,

I realize a psa test might open a can of worms for you but the fact that you're asking about it here seems to suggest that it's on your mind and you probably need to know the answer. A psa test is easy to get of course and still doesn't commit you to any follow up treatment, given they're only guideline type starting point.

As a next step, it could be worthwhile to ask if you could have a PSMA PET scan. These are [usually] more revealing than an MRI scan and they use marker dies of various sorts to highlight any cancer. This type of scan would not have been available when you had your initial diagnosis.

At age 75 I had hormones as part of some RT treatment but I really would not have liked to stay on them for a moment longer than it was absolutely necessary.

Decisions on treatment are so hard and different specialists can disagree which doesn't make life any easier.

Jules

User
Posted 12 Jun 2024 at 10:08

Hello Jules

Thanks for your helpful reply. I am getting the general sense from the supportive replies I have had that many people feel that the PSA/MRI route is my most suitable option. You are quite right that it is on my mind and I am still undecided. 

I had not heard about a PSMA PET scan and will look into it - thanks.

I see that you have had some treatment and hope you are now well.

Best wishes

'Richy'

User
Posted 12 Jun 2024 at 13:04

Thanks Richy,

I can understand your dilemna given the history and the length of time for which you've been untroubled by your prostate.

I did indeed go through a fair amount of HT and RT three years ago and I'm now clear of anything detectable. Never say never but it's looking good.

In my case the PET scan picked up some cancer in 3 lymph nodes, so with current, precise LINAC RT it was possible to hit these targets as well as the prostate but that side of things is probably not relevant to you.

Jules

User
Posted 13 Jun 2024 at 09:50

Hi Jules

Very pleased to hear it's looking good.

Best wishes

Richy

 
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