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Use of LHRH antagonists

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User
Posted 17 Aug 2024 at 12:05

Hi all, 

I've had a reoccurrence of my cancer. It was stage 3 (locally advanced) at initial diagnosis when I had surgey. 

After discussion with my consultant it's been recommended 2 years of hormones and radiation in 3-6 months which should provide excellent outcomes. Should I feel I don't get on with the hormones I can stop at 6 months and still have highly favourable outcomes. 

My first injection is due next week and I'm currently on LHRH antagonists tablets which are due to stop a week or so after my first injection.

Currently I seem to be handling these well and was wondering if anyone knew if I could use this as my hormone treatment rather than the injections and continue to see how I get on. I have read that this can be an option but wondered if anyone had any experience. 

User
Posted 17 Aug 2024 at 15:57

What drug are the tablets, Bicalutamide (anti-androgen), or Relugolix/Orgovyx (LHRH antagonist)? I've not heard of Relugolix being used to protect against Testosterone flare in the UK, although I imagine it would work.

For initial radical radiotherapy, hormone therapy halves the recurrence rate in some circumstances. I think less is known about the effectiveness of hormone therapy in salvage radiotherapy.

Edited by member 17 Aug 2024 at 15:58  | Reason: Not specified

User
Posted 18 Aug 2024 at 09:48

Treatment plan is based on a study that has only recently been published that followed participants for 10 years. The hormones make a significant difference from the study. Ill see if I can find it. Even if it just ended up being 6 months there is still significant improvement in outcomes vs no hormones. And yes, apologies it's Bicalutamide I'm taking. 

Edited by member 18 Aug 2024 at 09:59  | Reason: Not specified

User
Posted 18 Aug 2024 at 10:10

Hi my OH is on bicalutamide for two years, having had 20 sessions of RT for his reoccurrence. He seems to be a bit unusual as most men I’ve read seem to have injections but that is what his consultant offered him. He seems to be tolerating the bicalutamide quite well. He’s currently a bit fatigued, but we think that’s the effects of the RT.

User
Posted 18 Aug 2024 at 12:21

Originally Posted by: Online Community Member

Hi my OH is on bicalutamide for two years, having had 20 sessions of RT for his reoccurrence. He seems to be a bit unusual as most men I’ve read seem to have injections but that is what his consultant offered him. He seems to be tolerating the bicalutamide quite well. He’s currently a bit fatigued, but we think that’s the effects of the RT.

If I ever had to back on HT(it would be for life I’ve been told)  I would be asking if Bicalutamide was an option to try. I hate these HT Injections and what they’ve done to me…and I’m not alone😩
I might even consider having an orchidectomy rather than be on these jabs for life.

 

User
Posted 18 Aug 2024 at 13:39

Hi Decho

agreed- I think he’s been lucky to escape the injections at this stage! 🤞long may it continue. Poor thing is now struggling with pain in a testicle due to what we hope is a cyst and not anything more sinister. Now fast tracked for a scan. It just feels a bit relentless at the moment.

hope you are still having a wonderful time on your cruise! Kate

User
Posted 18 Aug 2024 at 20:54

Hi Andy. I’ve been recently diagnosed almost exactly the same diagnosis as you. Hence my reaching out. I’ve chosen the Hormone/HDRBrachyBoost/Radiotherapy route. As I’m new to this forum I was unable to send you a private message 

 
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