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Radical Prostatectomy Versus Stereotactic Radiotherapy for Clinically Localised Prostate Cancer

User
Posted 15 Sep 2024 at 11:25

Radical Prostatectomy Versus Stereotactic Radiotherapy for Clinically Localised Prostate Cancer: Results of the PACE-A Randomised Trial


"SBRT was associated with less patient-reported urinary incontinence and sexual dysfunction, and slightly more bowel bother than prostatectomy."


A relatively small sample, but the results are what you'd expect and probably similar for prostatectomy versus standard external beam radiotherapy. Difference in urinary continence and sexual function outcomes were large.

User
Posted 15 Sep 2024 at 15:30

The PACE-A trial treatment has been a standard of care for almost a year now (except, I think only the original trial sites have probably rolled it out generally so far, and still many sites can't do SABR even thought their LINACs may be technically capable). Two members of one of my support groups have had it over the last 9 months, although they both come under Mount Vernon which has been doing SABR for a long time (they had the first Cyberknife in the UK, well before standard LINACs could do SBRT).


I'm a bit skeptical of using SBRT for all the pelvic lymph nodes - hitting them all with SABR sounds like quite a challenge, but I don't know the trial details.


HDR Boost (standard external beam at reduced dose often including all pelvic lymph nodes, plus a boost of HDR Brachy to the prostate and optionally SV's) has proven very good in this case. There is a trial where the HDR Brachy part is replaced by SBRT, i.e. SBRT to prostate (and SV's for T3b) and standard external beam at a low dose to area where micro-mets may reside just like with HDR Boost. I'm guessing it will be 16 or 23 sessions, like HDR Boost, but I haven't read the trial protocol.


Treating without HT is because the current 5 fraction SABR treatment is only used in cases where no micro-mets are likely. If you have micro-mets in a low dose or no dose area, then you'll need HT to knock them out.

User
Posted 15 Sep 2024 at 18:25

Originally Posted by: Online Community Member


...The other thing that has always interested me is whether SBRT could ever be used for salvage treatment after prostatectomy failure?



My guess is, No (or not yet). It seems SBRT can be used against distant mets. Dr Kwon being an advocate of this, but I think in these cases one is talking about clear targets. I am inclined to think that if the prostatectomy didn't remove all the cancer, the remaining cells are 'somewhere near' the original site, so a wider beam has more chance of getting lucky and hitting the cancer.


It's quite possible that as scans improve, in the future, it may be possible to spot micro mets, which are currently invisible, and target SBRT at them.

Dave

User
Posted 15 Sep 2024 at 11:25

Radical Prostatectomy Versus Stereotactic Radiotherapy for Clinically Localised Prostate Cancer: Results of the PACE-A Randomised Trial


"SBRT was associated with less patient-reported urinary incontinence and sexual dysfunction, and slightly more bowel bother than prostatectomy."


A relatively small sample, but the results are what you'd expect and probably similar for prostatectomy versus standard external beam radiotherapy. Difference in urinary continence and sexual function outcomes were large.

User
Posted 15 Sep 2024 at 20:04

After RARP surgery,then salvage RT to the prostate bed ,I have twice had two separate courses of SABR treatment to two separate pelvic tumors. I didn't have HT with the original SRT, I didn't have any HT with the first  course of SABR treatment and had six months of Bicalutamide with the second course of SABR treatment. Each course was 5 sessions. 


My oncologist did say he suspected I may have metastatic disease before my first PSMA  scan , but that scan did pick up a tumor, so the first SABR treatment was carried out. The same thing happened before the second course of SABR treatment.


The third PSMA scan did not detect a tumor so at this point he more or less says I have micro mets and we await a further rise in my PSA to 3 before another PSMA scan, I assume if that scan detects a tumor it may be treated. It is worth noting I am now being treated privately and the NHS approach may differ.


Are the SABR treatments to the two lymph nodes still classed as salvage treatment or is there a different terminology.


Thanks Chris 

User
Posted 15 Sep 2024 at 21:56

I think that would count as a salvage treatment, given it wasn't planned as part of the first curative treatment.

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User
Posted 15 Sep 2024 at 13:35

Hi Andy.


The participants had low grade cancer, T2, PSA less than or equal to 20, Gleason less than or equal to 7 (3+4). I suspect most would have been eligible for AS?


I'd be interested to see how SBRT faired against high risk cancer. I thought our PCUK were trialling this?


https://prostatecanceruk.org/research/research-we-fund/ma-ct20-005


Am I correct in saying that the other huge advantages of SBRT is it is only 5 sessions and without HT?


The other thing that has always interested me is whether SBRT could ever be used for salvage treatment after prostatectomy failure?

User
Posted 15 Sep 2024 at 15:30

The PACE-A trial treatment has been a standard of care for almost a year now (except, I think only the original trial sites have probably rolled it out generally so far, and still many sites can't do SABR even thought their LINACs may be technically capable). Two members of one of my support groups have had it over the last 9 months, although they both come under Mount Vernon which has been doing SABR for a long time (they had the first Cyberknife in the UK, well before standard LINACs could do SBRT).


I'm a bit skeptical of using SBRT for all the pelvic lymph nodes - hitting them all with SABR sounds like quite a challenge, but I don't know the trial details.


HDR Boost (standard external beam at reduced dose often including all pelvic lymph nodes, plus a boost of HDR Brachy to the prostate and optionally SV's) has proven very good in this case. There is a trial where the HDR Brachy part is replaced by SBRT, i.e. SBRT to prostate (and SV's for T3b) and standard external beam at a low dose to area where micro-mets may reside just like with HDR Boost. I'm guessing it will be 16 or 23 sessions, like HDR Boost, but I haven't read the trial protocol.


Treating without HT is because the current 5 fraction SABR treatment is only used in cases where no micro-mets are likely. If you have micro-mets in a low dose or no dose area, then you'll need HT to knock them out.

User
Posted 15 Sep 2024 at 18:25

Originally Posted by: Online Community Member


...The other thing that has always interested me is whether SBRT could ever be used for salvage treatment after prostatectomy failure?



My guess is, No (or not yet). It seems SBRT can be used against distant mets. Dr Kwon being an advocate of this, but I think in these cases one is talking about clear targets. I am inclined to think that if the prostatectomy didn't remove all the cancer, the remaining cells are 'somewhere near' the original site, so a wider beam has more chance of getting lucky and hitting the cancer.


It's quite possible that as scans improve, in the future, it may be possible to spot micro mets, which are currently invisible, and target SBRT at them.

Dave

User
Posted 15 Sep 2024 at 20:04

After RARP surgery,then salvage RT to the prostate bed ,I have twice had two separate courses of SABR treatment to two separate pelvic tumors. I didn't have HT with the original SRT, I didn't have any HT with the first  course of SABR treatment and had six months of Bicalutamide with the second course of SABR treatment. Each course was 5 sessions. 


My oncologist did say he suspected I may have metastatic disease before my first PSMA  scan , but that scan did pick up a tumor, so the first SABR treatment was carried out. The same thing happened before the second course of SABR treatment.


The third PSMA scan did not detect a tumor so at this point he more or less says I have micro mets and we await a further rise in my PSA to 3 before another PSMA scan, I assume if that scan detects a tumor it may be treated. It is worth noting I am now being treated privately and the NHS approach may differ.


Are the SABR treatments to the two lymph nodes still classed as salvage treatment or is there a different terminology.


Thanks Chris 

User
Posted 15 Sep 2024 at 21:56

I think that would count as a salvage treatment, given it wasn't planned as part of the first curative treatment.

 
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