Brutal increase in PSA level in 3 months

The antibiotic treatment was for 14 days and the PSA test was performed

10 days after finishing the antibiotic treatment.

I expected the urologist to culture bacteria from semen and urine before prescribing antibiotics,

but I don't understand why he did it the other way around.

Now we do not know if the possible inflammation was due to an infection or not :(

I am tremendously anxious and very afraid that something aggressive has appeared

again in my prostate and I will have to leave AS.

I am truly terrified of surgery and its unpleasant side effects since I am still very young.

B.R.

I am scheduled for an MRI on December 17th and then discuss the results on December 27th.

I hope this gleason 6 tumor has not suffered a mutation of such magnitude.

I am aware that in medicine 0% and 100% do not exist, but there are several cases

in this forum of members with an initial Gleason 6 tumor that progressed

to much more aggressive forms in not much time, unfortunately.

All of this contrasts with the large number of articles in the literature

in which some go so far as to state that Gleason 6 is indolent/harmless.

B.R.

Hi friends.. Update News 27/12/2024

MRImp. PSA total: 5.59 ng/ml

Clinical indication:
Prostate carcinoma under active surveillance.

Findings:
A pelvic and multipara prostate study was performed according to the usual protocol, including
perfusion sequences after the administration of intravenous iodinated contrast.
Prostate of approximately 48 x 37 x 27 mm, diameters that correspond to a volume of
24.9cc.
Adenomatous changes in the transitional zone.
No alterations are seen in the right peripheral lobe.
An area of ​​T2 hyposignal persists in the inferolateral margin of the left peripheral lobe.
ill-defined contour with discrete diffusion restriction, which corresponds to the lesion
described in the previous study, not appreciating significant changes.
There are no alterations in the prostate contour, with good delimitation of the bands.
neurovascular.
There are no bone signal alterations suggestive of secondary lesions or
lymphadenopathy of relevant size.

Conclusion:
Exploration without significant changes compared to previous.
No new lesions are seen.

B.R.

Yeah, drink for me!! 😀

hello... well next week must be make new PSA control...

After my last MRI scan three months ago, which showed a stable Gleason 6 tumor and no new lesions, The PSA value 5.59 too 3 months ago.
I'm once again panicking and experiencing very high anxiety about the possible PSA results.

Edited by member 27 Mar 2025 at 19:56  | Reason: Not specified

30/05/2022: 4.14 ng/ml

25/09/2023: 5.33 ng/ml

12/06/2024: 5.85 ng/ml

27/09/2024: 35.80 ng/ml (prostatitis)

30/10/2024: 11.70 ng/ml (prostatitis)

13/12/2024: 5.59 ng/ml

28/03/2025: 4.80 ng/ml

10/09/2025: 9.54 ng/ml

Plan: Permixon 2 capsules a day until repeat PSA in 3 months and new MRI and securely new biopsy.

tremendously anxious!!

Hello friends merry xmas. Update MRI AS.

i think radiologic progression. Bad news, big sh*t

Multiparametric MRI – December 2025

• Prostate volume: 29.55 cc.
• Lesion: nodular lesion of approximately 13 mm in the inferior third of the left peripheral lobe, hypointense on T2 with significant diffusion restriction, fulfilling criteria for PI-RADS 4, described as the same lesion already seen in previous studies.
• Small bands of nonspecific fibrosis in the right peripheral lobe.
• Adenomatous changes in the transition zone with a slightly enlarged median lobe.
• No capsular irregularity or signs of extracapsular extension, neurovascular bundles well preserved.
• Seminal vesicles with normal morphology and signal.
• No bladder wall lesions.
• No suspicious bone lesions in the field of view and no pelvic/inguinal lymphadenopathy of significant size.
• Rectum and perineal region without relevant findings.

Conclusion (Dec 2025 MRI):

Single 13 mm PI-RADS 4 nodular lesion in the inferior margin of the left peripheral lobe, corresponding to the known tumor focus, still confined to the prostate, without radiological evidence of extracapsular extension, seminal vesicle invasion, lymph node involvement or bone metastasis.

hi mate merry Xmas.

nexr step is new TP biopsy 23 january.

now lession is more nodular and more 2-3 mm size but the most concerning is from discrete diffusion restriction to significant. Maybe now not is gleason 6.!!

Again, I'm experiencing a lot of anxiety and sharp pains in my chest. I'm terrified of RALP and incontinence.

Hello mate thank u very much

MRI only showed one focus 13mm (10x11 mm at diagnosis two years ago). Psa at diagnosis 5.33 PSA last year

dec 2024: 5.59
apr 2025: 4.80

Sept 2025: 9.54

dec 2025: 7.87

I'd also heard from some specialists that Gleason 6 Isup 1 doesn't mutate, but I've read about many upgrade cases on this same forum, perhaps due to undersampling in the initial biopsy. What worries me most right now is the 2-3 mm growth since diagnosis and, above all, the increase in diffusion restriction. I'm very apprehensive and experiencing a lot of anxiety because I suspect RALP is too close.

Hi Murdock

My husband is currently on ADT waiting for the RT to start later in the year. 

You sound very depressed as I'm sure you know. Your PSA still sounds low. I'm no expert but I think you need reassurance more than anything. I think you've been so depressed for such a long time it's a hard one to shake off. But you will. I've had experience of being ill with anxiety.  It's horrible 

Yes you are right to feel worried, right to be concerned what will be the very best treatment for you, no one can down play that. But that's different from being ill with anxiety and depression.  

Do ask someone for help and guidance. You do need some solid support around you. Perhaps try ringing the Prostate cancer nurses from the number on this website . I'm wishing you the best 

Hi Murdock

We actually feel OK

His father had Prostate cancer in1990 and lived till 2021, passing away at 93. RT was bit cruder then but he did extremely well. 

We have just confirmed a holiday for June, and looking forward to taking granddaughters out. He is fit and active, in every sense of the word. Being able to go walking a lot straight from our house into the countryside, we feel is very lucky. He has a supportive GP. We are glad it's being treated, and that we live a fairly close ride to hospital. 

Sex is still great and we are prepared to do whatever it takes to keep it like that as I have always had a very high sexdrive, and so has he. I am working on making our diet healthier , cutting out red meat, processed food, and going organic.

We have an allotment we like to both work on so he dug up some leeks today for leek and potato soup. 

I think the important thing is to try to gain a kind of control so you feel less of a victim. That does help to lift some of the anxiety. 

Unfortunately you are still in the worst place,  waiting. Once you know what's going on, and have a plan I do feel your mood will improve. Stay as calm as you can, and just time pass  

I did find a research document that had come to the conclusion that red meat and processed meat do not cause or contribute to developing (prostate) cancer, but an absence of these elements in the diet can be an environment that cancer cells find difficult to thrive in. I'm sure it's a minute difference, but if we're enjoying our diet, then why not! I'm afraid I didn't make a note of where I found this, but it sort of made sense to me. 

Anyway we enjoy salmon, fish, have a neighbour who is vegetarian, who cooks delicious meals. We eat a fair amount of chicken and do enjoy a pork roast too. Overall we have a reasonably varied diet. 

Edited by member 24 Jan 2026 at 09:13  | Reason: Not specified

Actually all the evolutionary evidence points to the opposite, we thrive on a carnivore diet and survive on a "varied" diet. 5000 years ago northern Europeans ate animal products and occasional seasonal berries.

Hello friends

Today is probably the saddest day of my life, which I fear is going to change for the worse.

after 2 years of active surveillance for a Gleason 6 tumor of 10x11 mm and currently of 13 mm and Gleason 7 (3+4).
3 positive Gleason cores (3+4) directed to the index lesion with 60% involvement. In the left lobe.

Another positive Gleason 6 nucleus also appeared with 20% involvement, also in the left lobe.

not perineural present

not  limphovascular present

nor EPE

Now I must decide between RALP or MRI Linac.

I am very afraid of the operating room, the anesthesia, the postoperative pain, and especially of incontinence and ED.

I'm crying like a baby as I write this message. Without a doubt, the worst day of my life.

My best wishes to all of you; any help, opinion, or suggestion will be greatly appreciated.

Edited by member 06 Feb 2026 at 05:27  | Reason: Not specified

Murdock, I sailed through surgery, loved the whole general anesthetic experience. I was 99 percent dry 4 days after catheter removal. Okay I had ED but had fun finding a solution. The only pain I got post op was due to constipation. 

Post op they found the cancer at the edge of the prostate an subsequently it was found outside of the prostate and prostate bed. I was diagnosed when imaging was not as good sand I probably had cancer at least 12 years before diagnosis.I am now 12 years on from diagnosis now on HT and not planning on dying just yet.

Good luck with your choice, surgery and RT both have similar success rates. RT treatment is less traumatic than surgery, HT can be more debilitating than post op surgery,but you can always stop HT.

Thanks Chris 

Hello mate, all the doctors I consulted recommend radical treatment due to my age (54 years) and family history.

Hi Peter, thank you so much for your comforting words. I'm going to explore your recommendation and look for a support group because I'm really going through a tough time. I have insomnia and my mind is filled with negative thoughts. I wish you all the best.

Dear Adrian, since my initial diagnosis in 2023, you have been one of my main sources of support here, and I have a lot of appreciation for you. Reading your posts has brought me some relief during the toughest times. I definitely need psychological help, as I've only just begun this journey, and aside from the panic, I feel completely exhausted. I'm on disability leave from work. I can't sleep well; my mind is constantly racing with post-surgery pain, the catheter, incontinence, ED, biochemical recurrences, radiation, more toxicity, and more long-term effects. I'm trying my best to keep my 10-year-old daughter from seeing me cry or suffer. She's had nightmares for years about losing her parents someday, and when she sees me after surgery with the wounds in my abdomen and the catheter, she's going to suffer a lot, and that tears me apart. I hope you're doing well, and I would love to be able to talk to you calmly and privately. Best wishes.