Hi all, got out of the habit of posting this year so back with a vengeance 😎
5 and a bit years down the line and the Decapeptyl jabs and Bical tabs are now starting to lose their effect.
3 consecutive PSA rises after my check up with the consultant this week so it appears to be time for a change of tack. Bicalutamide has been stopped, hopefully with a bit of Casodex withdrawal response.
Next up is a CT+AB scan plus a full bone scan looking to see what might be causing the rise.
Once the results are in, my approachable consultant would like to see me again, and thinks the way ahead will be either Enzalutamide or Abiraterone with Olaparib, and has given me handouts on both options to think about which way I might like to proceed.
I honestly haven't a clue so thought I would sound out opinion on here?
My understanding so far is Enza is more straightforward to take than Abi and also that the Abi/Olaparib with steroids route can potentially have more serious side effects (though I am aware not everyone gets hit with all the serious side effects). The overall effectiveness seems to be broadly similar from what I can find?
So, would anyone who is either on Enza or Abi after becoming resistant to first line HT care to share their thoughts on ease of use and/or side effects?
Edited by member 15 Oct 2024 at 18:28
| Reason: Not specified
Good luck to everyone coping with the insidious big C |
User
Hi
I was on Enza for 16 months until it started to fail I think it's the better of the too.
I was tested for olaparib but didn't have the gene so not eligible.
Regards Phil
User
Hi Phil, I haven't got Braca mutation either but apparently it works with abiraterone regardless?
From the NICE website - "Clinical trial evidence shows that olaparib with abiraterone and prednisone or prednisolone increases how long people live and how long they have before their cancer gets worse compared with abiraterone alone. Olaparib with abiraterone and prednisone or prednisolone has not been directly compared with enzalutamide".
Shame there's no study comparing it with Enza 😔
Stay strong
Steve
Good luck to everyone coping with the insidious big C |
User
Hi Steve, I went on to Enza Feb' 21 combined with Decapeptyl injections when my PSA started to rise plus 30 days of Bicalutamide, my PSA dropped very quickly and over the next years my dose went from 4 down to 2 tablets a day to help with fatigue and brain fog. Now thinking of adding a low dose steroid to stop the rise ( I'm only at 0.3 but it has been rising for 6 months) so idea to nip it in the bud early.
Hope this helps annoyingly people say how well I'm looking but honestly I feel as though I want to do things even if I have to do it slowly
DaveH
Edited by member 16 Oct 2024 at 15:09
| Reason: Not specified
User
Thanks Dave, just trying to compare the health implications between the two regimes. Both seem to have associated blood pressure/heart/stroke possibilities. I'm already on statins for cholesterol, a family trait, so just ordered a blood pressure monitor to keep a record 😎
Good luck to everyone coping with the insidious big C |