Stay on AA or Brachy?

Not enough information to estimate progression.

However, you are mainly 3+4 now from what little I can derive versus 3+3 previously. 3+4 is not normally eligible for AA unless the 4 is almost insignificant, which makes me wonder why they are suggesting to stick with AA.

Hello mate.

I think that's a little strong. Autopsies of men who've died of other causes show a high percentage had intermediate prostate cancer without knowing it.

This research indicates that dependant on risk factors, Gleason 7 (3+4) can be deemed suitable for AS.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11034964/

Going through Bob's posts, when he was first diagnosed two and a half years ago, his PSA was only 3.3 and Gleason 6 (3+3)

So it does seem to have progressed. What would concern me more, is the disease seems bilateral and was once deemed T3a then downgraded to T2. Either way, it suggests it must be very close to the prostate wall.

Like you and Andy, this makes me wonder why the MDT have decided that AS is still appropriate.

Bob, what's your latest PSA?

Edited by member 27 Nov 2024 at 19:54  | Reason: Typos

Not necessarily! A lot depends on how much pattern 4 is contained within the cancer. In my own case (age 74) I was originally diagnosed 3+4 at the local hospital and only given treatment options but a second opinion of the biopsy slides by a reviewing pathologist at The Christie showed "minimal" pattern 4 involvement, ie less than 5% which is apparently regarded as much the same as 3+3. Evidence of this with me has been stable PSA levels over 2.5 years since diagnosis and 3 mpMRI scans in that time (latest earlier this month) showing no change in the prostate so AS was justified.