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Info please. 40 psa - 3+4 gleason

User
Posted 01 Dec 2024 at 19:02

I have only had my results from a specialist nurse by phone so far , as results only ready Friday and going to Cyprus for two weeks tomorrow, so will not get to speak to consultant until 23 December.  The nurse said it is ok to go. 

I am 72 , and am very fit despite some breathing problems from mild copd- I do a fast 4 mile walk every day and go to gym twice a week.  BMI is 25 but not overweight.

I had no symptoms of any prostate problems , apart from more frequent peeing , but had put that down to age !   The blood test was an annual one to keep an eye on my copd , but as I had never had my psa checked the nurse added it to the checklist.  It came back at 37 , and they did another test - 40.  I am already stressed by now !

I got fast tracked , and the mri gave me 2 fives 2 fours and 2 threes.    Scared to death now !   The nurse said the biopsy was a 3+4 Gleason - with 15 cores out of 30.   They do not thing the cancer has spread to my lymph nodes. She said the ‘committee meeting’ they have has recommended hormone therapy tablets and injections, with 20 sessions of radiotherapy, probably after 3 months.

So , my initial questions I forgot to ask the nurse.

 1. Why so many cores - it seems 12 to 20 is the norm 

2. It seems AS is not an option - is that because of the high core and psa scores ? 

3.  Is it possible to keep my ‘belly’ from expanding from the HT with exercise - I do not want to get fat !

4.  How long do most people have to stay on HT ?

I will probably have other questions but my mind is still trying to process everything !

User
Posted 01 Dec 2024 at 23:34

Originally Posted by: Online Community Member

 1. Why so many cores - it seems 12 to 20 is the norm 

2. It seems AS is not an option - is that because of the high core and psa scores ? 

3.  Is it possible to keep my ‘belly’ from expanding from the HT with exercise - I do not want to get fat !

4.  How long do most people have to stay on HT ?

1. 12 to 20 was the old standard trans rectal biopsy. New biopsies are trans perineal which is safer so more cores can be taken. The more cores taken the better the diagnosis.

2. High PSA, Gleeson above 3+3, large percent of cores. All these factors go against AS.

3. I don't know anyone who lost weight on HT. If you keep active on HT it probably won't go up too drastically. After you stop HT you will probably return to your former weight.

4. Two years would be fairly typical for HT. There is some argument that 18 months is enough. Some people just can't stand it within six months, but I can think of only one person on this site who found it that bad.

Edited by member 01 Dec 2024 at 23:35  | Reason: Not specified

Dave

User
Posted 01 Dec 2024 at 23:40

I agree 30 cores is more than usual, but in reality the more the better if they are looking at random for cancer. However, in your case with the MRI, if they did a fusion MRI directed biopsy they take additional cores from area’s of interest identified as abnormalities from the MRI. Most abnormality lesions are identified using a PIRADS grading system as to their likelihood of containing cancer. You mentioned nothing regarding that from your biopsy but I presume Gleason grades if a 7 (3+4) which is considered a favorable 7. I am not sure what is being referred to as two 5’s, two 4’s and two 6’s. Typically a Gleason 7 favorable versus a Gleason 7 unfavorable (4+3) is still questionable for AS. That is good they don’t believe it has gone to the lymph nodes but is anything mentioned of the prostate capsule appearing breeched also referred to as EPE (Extra Prostatic Extension) or reference to the seminal vesicles or perineural invasion? It seems the nurse may have quickly gone over the pathology report skipping some important points that may be eliminating Surgery as an option for you. I would try yo get her to send or upload a copy of the pathology report and push for a PSMA PET scan.

User
Posted 07 Jan 2025 at 18:58

An update.

I am now on hormone therapy - just had my first injection yesterday.    Because of my very high psa level at 40 , they reckon I might be on the HR for maybe 3 years.   I will be having 20 sessions of RT in April/may.    I asked if the 5 session of RT was available , but they said that the 40psa classes me as high risk , and that makes the 5 session unsuitable.  I was told that all my cancer appears to have been contained in my prostate.   They gave me a bone scan , and that is clear ( it has also given me additional info that my spine has some bad wear !).   Reading has advised that keeping fit , especially core exercises, is highly recommended.   

I have felt quite stressed for the last couple of months - I am going to a local support group tomorrow as I think sharing helps.   I have been seen and had my treatments at Blackpool Victoria hospital - and I have to say every member of staff I have had interaction with has been wonderful.

I suppose my story is quite average , and maybe similar to the path many are on.

User
Posted 08 Jan 2025 at 17:33
Good luck with your treatment plan, I've also been treated at Blackpool Victoria Hospital for the last

few years - always been provided with first rate treatment from Oncology and Urology departments.

User
Posted 08 Jan 2025 at 21:05

Originally Posted by: Online Community Member
I was told that all my cancer appears to have been contained in my prostate. They gave me a bone scan , and that is clear ( it has also given me additional info that my spine has some bad wear !).

Don't you hate that! Scans do tend to show up some of the wear and tear of life. I was told exactly the same thing about some lower spinal joints and oddly, a toe but I reckon you just take it as a mark of success if you're still functioning and fit despite such issues.

As you say, your fairly "average" but you're also in a relatively good place in that the cancer is contained and your treatment stands every chance of success. There's several of us here who've had EBRT for G9 cancer, sometimes locally advanced with success. The latest LINAC RT machines are very accurate and very effective.

As Dave says, you might not have to go through the full 3 years of HT after your RT but that will be determined along the way as your psa results come in. If they stay in the "low enough to be regarded as unmeasurable" class, it will be a good indicator for shortening your HT treatment time.

Jules

User
Posted 09 Jan 2025 at 08:29

Originally Posted by: Online Community Member

Originally Posted by: Online Community Member
They gave me a bone scan , and that is clear ( it has also given me additional info that my spine has some bad wear !).

Don't you hate that! Scans do tend to show up some of the wear and tear of life.

Hi gents.

I was also fortunate enough that my bone scan was negative for spread, but showed umpteen wear and tear 'injuries'. I think most were linked to arthritis. I'm beginning to feel like a clapped out old banger going on an MOT. The more they check the more failures they find. 🙂

sscrabble very best of luck with your treatment mate. To be average is good in this game.👍

 
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