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On AS but now changes in MRI

User
Posted 22 Jan 2025 at 08:46

Hi 

My husband been on AS for 7 years with 3+3 Gleason, psa has been stable. MRI now shows doubling in volume in the main focal area in last 2 yrs. results states more likely now a 4.  Luckily still localised. Appt tomorrow to discuss. What do we ask? Our feeling is go for surgery as can not face continued AS now with such a dramatic change. My husband is 61 and very fit and active. We are in shock but want to make the most of the telephone appt and get as much info as possible. Any advice welcome. Thank you Tricia & Phil

User
Posted 22 Jan 2025 at 09:27

Hi Tricia.

I'm sorry that you've had to find us, but welcome to the forum.

Was on active surveillance for two years when a follow up MRI showed tumour growth. Due to this, I was given a second biopsy. I'd have thought, prior to possible radical treatment, that would have been the next step for Phil?

If radical treatment is needed, at least by being on AS, Phil has had seven years without the possibilities of any side effects.

I wish you both good luck.👍

 

Edited by member 22 Jan 2025 at 09:48  | Reason: Additional text

User
Posted 22 Jan 2025 at 09:35

Thanks Adrian … what is the benefit of a biopsy apart from staging the cancer? The biopsy itself is invasive and takes while to recover? 

User
Posted 22 Jan 2025 at 10:04

The MRI only shows that the lesions have got bigger, they don't show any possible change in the Gleason score. Which may affect the choice of what, if any, radical treatment to have.

 However, if due to the apparent disease progression show by the MRI, Phil is intent on having radical treatment, then I suppose a further biopsy would be pointless. 

In my case, the apparent tumour progression shown on the follow up MRI, automatically triggered a follow up biopsy. Both results were considered when discussing further treatment options.  My disease had progressed from T2a prostate confined,  Gleason 6 (3+3), to T3a capsular breach, Gleason (3+5) later upgraded to Gleason 9(4+5). I selected robotic surgery but was also offered radiotherapy and hormone treatment.

 

Edited by member 22 Jan 2025 at 11:01  | Reason: Typo

User
Posted 22 Jan 2025 at 10:22

Thanks Adrian that’s really useful, it is far more complicated I suppose than just choosing surgery. Phil is under UCL so feel we are in the best place. Will see what they say at our appointment and take it from there. Thanks for response it’s a great help

 
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